Watt George, Lacroix Adele, Pachirat Orathai, Baggett Henry C, Raoult Didier, Fournier Pierre-Edouard, Tattevin Pierre
Global Disease Detection Center, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Université Rennes-1, Rennes, France; Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Division of Global Health Protection, US Centers for Disease Control and Prevention, Atlanta, Georgia; Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medicine, University of the Mediterranean, Marseille, France; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, INSERM U835, Université Rennes-1, Rennes, France
Global Disease Detection Center, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Université Rennes-1, Rennes, France; Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Division of Global Health Protection, US Centers for Disease Control and Prevention, Atlanta, Georgia; Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medicine, University of the Mediterranean, Marseille, France; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, INSERM U835, Université Rennes-1, Rennes, France.
Am J Trop Med Hyg. 2015 Apr;92(4):871-4. doi: 10.4269/ajtmh.14-0689. Epub 2015 Feb 2.
Prospectively collected, contemporary data are lacking on how the features of infective endocarditis (IE) vary according to region. We, therefore, compared IE in Rennes, France and Khon Kaen, Thailand. Fifty-eight patients with confirmed IE were enrolled at each site during 2011 and 2012 using a common protocol. Compared with French patients, Thais had a lower median age (47 versus 70 years old; P < 0.001) and reported more animal contact (86% versus 21%; P < 0.001). There were more zoonotic infections among Thai than France patients (6 and 1 cases; P = 0.017) and fewer staphylococcal infections (4 versus 15 cases; P = 0.011). Underlying rheumatic heart disease was more prevalent in Thai than in French patients (31% and 4%; P = 0.001), whereas prosthetic heart valves were less prevalent (9% and 35%; P = 0.001). Our data strengthen previous observations that IE in the tropics has distinctive demographic characteristics, risk factors, and etiologies and underscore the need for improved prevention and control strategies.
目前缺乏关于感染性心内膜炎（IE）特征如何因地区而异的前瞻性收集的当代数据。因此，我们比较了法国雷恩和泰国孔敬的IE情况。2011年和2012年期间，在每个地点使用共同方案招募了58例确诊为IE的患者。与法国患者相比，泰国患者的年龄中位数较低（47岁对70岁；P<0.001），且报告的动物接触更多（86%对21%；P<0.001）。泰国患者中的人畜共患感染比法国患者更多（6例和1例；P=0.017），葡萄球菌感染更少（4例对15例；P=0.011）。潜在的风湿性心脏病在泰国患者中比法国患者更普遍（31%和4%；P=0.001），而人工心脏瓣膜则不那么普遍（9%和35%；P=0.001）。我们的数据强化了之前的观察结果，即热带地区的IE具有独特的人口统计学特征、风险因素和病因，并强调了改进预防和控制策略的必要性。
