白藜芦醇通过靶向致癌性微小RNA和多种信号通路抑制胶质瘤细胞生长。
Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways.
作者信息
Wang Guangxiu, Dai Fang, Yu Kai, Jia Zhifan, Zhang Anling, Huang Qiang, Kang Chunsheng, Jiang Hao, Pu Peiyu
机构信息
Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
出版信息
Int J Oncol. 2015 Apr;46(4):1739-47. doi: 10.3892/ijo.2015.2863. Epub 2015 Feb 2.
Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.
白藜芦醇（Res）是一种天然多酚化合物，在多种癌症中具有抗癌活性。在本研究中，研究了Res对大鼠C6胶质瘤生长的抗肿瘤作用及其潜在分子机制。结果表明，Res在体外抑制胶质瘤细胞增殖，使细胞周期停滞于S期并诱导细胞凋亡。Res还在体内抑制颅内C6肿瘤生长，并延长了部分颅内胶质瘤大鼠的生存期。Res显著下调了特定的微小RNA（miR），包括miR-21、miR-30a-5p和miR-19，这些在我们之前的研究中已被鉴定为癌基因miR，并改变了它们的靶向基因以及胶质瘤形成和进展的关键基因的表达，如p53、PTEN、EGFR、STAT3、COX-2、NF-κB和PI3K/AKT/mTOR通路。因此，Res的抗胶质瘤作用至少部分是通过调控致癌性微小RNA实现的。Res对非编码RNA的作用有待进一步研究。Res是一种治疗胶质瘤的潜在多靶点药物。
Zotero 插件