Ibrahim Raghad Sabaawi, Ibrahim Shahad Sabaawi, El-Naas Ahmed, Koklesová Lenka, Kubatka Peter, Büsselberg Dietrich
Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Cancers (Basel). 2023 Jun 27;15(13):3368. doi: 10.3390/cancers15133368.
Glioblastoma, a malignant brain tumor, is a common primary brain tumor in adults, with diabetes mellitus being a crucial risk factor. This review examines how the antidiabetic drug metformin and dietary supplement resveratrol can benefit the treatment of glioblastoma. Metformin and resveratrol have demonstrated action against relevant pathways in cancer cells. Metformin and resveratrol inhibit cell proliferation by downregulating the PI3K/Akt pathway, activating mTOR, and increasing AMPK phosphorylation, resulting in lower proliferation and higher apoptosis levels. Metformin and resveratrol both upregulate and inhibit different cascades in the MAPK pathway. In vivo, the drugs reduced tumor growth and volume. These actions show how metformin and resveratrol can combat cancer with both glucose-dependent and glucose-independent effects. The pre-clinical results, alongside the lack of clinical studies and the rise in novel delivery mechanisms, warrant further clinical investigations into the applications of metformin and resveratrol as both separate and as a combination complement to current glioblastoma therapies.
胶质母细胞瘤是一种恶性脑肿瘤，是成人常见的原发性脑肿瘤，糖尿病是一个关键风险因素。本综述探讨了抗糖尿病药物二甲双胍和膳食补充剂白藜芦醇如何有益于胶质母细胞瘤的治疗。二甲双胍和白藜芦醇已证明对癌细胞中的相关途径有作用。二甲双胍和白藜芦醇通过下调PI3K/Akt途径、激活mTOR和增加AMPK磷酸化来抑制细胞增殖，从而导致较低的增殖水平和较高的凋亡水平。二甲双胍和白藜芦醇均上调并抑制MAPK途径中的不同级联反应。在体内，这些药物可减少肿瘤生长和体积。这些作用表明二甲双胍和白藜芦醇如何通过葡萄糖依赖性和非葡萄糖依赖性作用来对抗癌症。临床前结果，加上缺乏临床研究以及新型给药机制的兴起，有必要对二甲双胍和白藜芦醇作为单独药物以及作为当前胶质母细胞瘤治疗的联合补充剂的应用进行进一步的临床研究。
