Butler Elissa K, Hume Heather, Birungi Isaac, Ainomugisha Brenda, Namazzi Ruth, Ddungu Henry, Kajja Isaac, Nabadda Susan, McCullough Jeffrey
University of Minnesota Medical School, Minneapolis, Minnesota.
School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Transfusion. 2015 May;55(5):1058-66. doi: 10.1111/trf.13010. Epub 2015 Feb 3.
A safe and adequate supply of blood is critical to improving health care systems in sub-Saharan Africa, where little is known about the current use of blood. The aim of this study was to comprehensively describe the use of blood at a tertiary care hospital to inform future efforts to strengthen blood programs in resource-limited settings.
Data were collected from blood bank documentation for all units issued at Mulago Hospital Complex in Kampala, Uganda, from mid-January to mid-April 2014.
A total of 6330 units (69% whole blood, 32% red blood cells, 6% platelets, 2% plasma) were issued over the 3-month study period to 3662 unique patients. Transfusion recipients were 58% female and median age was 27 years (interquartile range [IQR], 14-41). Median pretransfusion hemoglobin was 5.6 g/dL (IQR, 4.0-7.2 g/dL, n = 1090). Strikingly, cancer was the top indication for transfusion (33.5%), followed by pregnancy-related complications (12.4%) and sickle cell disease (6.9%).
This study provides a comprehensive picture of blood use at a national referral hospital in sub-Saharan Africa. Noncommunicable diseases, particularly oncologic conditions, represent a large proportion of demand for transfusion services.
安全充足的血液供应对于改善撒哈拉以南非洲的医疗保健系统至关重要，而目前对该地区血液使用情况知之甚少。本研究的目的是全面描述一家三级护理医院的血液使用情况，为今后在资源有限地区加强血液项目的工作提供参考。
收集了2014年1月中旬至4月中旬乌干达坎帕拉穆拉戈医院综合院区所有发放单位的血库记录数据。
在为期3个月的研究期间，共向3662名不同患者发放了6330个单位的血液（69%为全血，32%为红细胞，6%为血小板，2%为血浆）。输血接受者中女性占58%，中位年龄为27岁（四分位间距[IQR]，14 - 41岁）。输血前血红蛋白中位数为5.6 g/dL（IQR，4.0 - 7.2 g/dL，n = 1090）。值得注意的是，癌症是输血的首要指征（33.5%），其次是妊娠相关并发症（12.4%）和镰状细胞病（6.9%）。
本研究全面呈现了撒哈拉以南非洲一家国家级转诊医院的血液使用情况。非传染性疾病，尤其是肿瘤疾病，占输血服务需求的很大比例。
