van Boeckel Petra G A, Siersema Peter D
Department of Gastroenterology and Hepatology, HP: F02.618, University Medical Center, Heidelberglaan 100, 3584, CX, Utrecht, Netherlands,
Curr Treat Options Gastroenterol. 2015 Mar;13(1):47-58. doi: 10.1007/s11938-014-0043-6.
Benign esophageal strictures arise from a diversity of causes, for example esophagogastric reflux, esophageal resection, radiation therapy, ablative therapy, or the ingestion of a corrosive substance. Most strictures can be treated successfully with endoscopic dilation using bougies or balloons, with only a few complications. Nonetheless, approximately one third of patients develop recurrent symptoms after dilation within the first year. The majority of these patients are managed with repeat dilations, depending on their complexity. Dilation combined with intra lesional steroid injections can be considered for peptic strictures, while incisional therapy has been demonstrated to be effective for Schatzki rings and anastomotic strictures. When these therapeutic options do not resolve the stenosis, stent placement should be considered. Self bougienage can be proposed to a selected group of patients with a proximal stenosis. As a final step surgery is an option, but even then the risk of stricture formation at the anastomotic site remains. This chapter reviews refractory benign esophageal strictures and the treatment options that are currently available.
良性食管狭窄由多种原因引起,例如食管胃反流、食管切除术、放射治疗、消融治疗或腐蚀性物质摄入。大多数狭窄可通过使用探条或球囊进行内镜扩张成功治疗,并发症较少。尽管如此,约三分之一的患者在扩张后第一年内会出现复发症状。这些患者中的大多数根据其复杂程度接受重复扩张治疗。对于消化性狭窄,可考虑扩张联合病灶内注射类固醇,而切开治疗已被证明对沙茨基环和吻合口狭窄有效。当这些治疗选择无法解决狭窄问题时,应考虑放置支架。对于选定的近端狭窄患者,可建议进行自我探条扩张。作为最后一步,手术是一种选择,但即便如此,吻合口处仍有形成狭窄的风险。本章回顾难治性良性食管狭窄及目前可用的治疗选择。
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