Li Xiaolin, Fu Jie, Xue Yan, Yang Yang, Wang Yang, Zhang Cixian, Zhuo Shichao, Irani Farzan
Department of Hematology, Xuzhou Central Hospital, 199 South Jiefang Rd, Xuzhou, 221009, Jiangsu, People's Republic of China.
Department of Pathology, Xuzhou Central Hospital, Xuzhou, Jiangsu, People's Republic of China.
Cell Biochem Biophys. 2015 Jul;72(3):791-4. doi: 10.1007/s12013-015-0534-7.
Primary granulocytic sarcoma (GS) is an uncommon, extramedullary proliferation of myeloid cells, occurring in the absence of antecedent myeloproliferative disorder. Breast involvement is uncommon. A diagnosis of GS portends a poor prognosis. Even with intensive chemotherapy for AML, progression to overt leukemia can be delayed for 2-3 years. We, report a 29-year-old man who presented with a painless, left breast lump. A modified radical mastectomy followed by histopathological and immunohistochemical testing confirmed a granulocytic sarcoma. There was no evidence of a concurrent leukemia. Intensive chemotherapy for acute myelogenous leukemia was instituted. Allogenic hematopoietic stem cell transplantation was successfully given. The patient remains in complete remission at follow-up. We highlight the importance of timely diagnosis of this uncommon entity with institution of intensive therapy. Early use of allogenic bone marrow transplantation in the treatment of primary GS may be warranted.
原发性粒细胞肉瘤（GS）是一种罕见的髓样细胞髓外增殖，发生于既往无骨髓增殖性疾病的情况下。乳腺受累并不常见。GS的诊断预示着预后不良。即使采用强化化疗治疗急性髓细胞白血病（AML），进展为明显白血病的时间也可延迟2至3年。我们报告一名29岁男性，其表现为左侧乳房无痛性肿块。改良根治性乳房切除术后进行组织病理学和免疫组织化学检测，确诊为粒细胞肉瘤。没有并发白血病的证据。开始对急性髓性白血病进行强化化疗。成功进行了异基因造血干细胞移植。随访时患者仍处于完全缓解状态。我们强调及时诊断这一罕见疾病并进行强化治疗的重要性。早期使用异基因骨髓移植治疗原发性GS可能是必要的。
