急性粒单核细胞白血病异基因干细胞移植后粒细胞肉瘤的乳腺和脊柱复发：一例报告
Breast and dorsal spine relapse of granulocytic sarcoma after allogeneic stem cell transplantation for acute myelomonocytic leukemia: A case report.
作者信息
Li Yuan, Xie Yu-De, He Shao-Jie, Hu Jia-Mei, Li Zhi-Sheng, Qu Shao-Hua
机构信息
Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China.
Department of Orthopaedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China.
出版信息
World J Clin Cases. 2022 Mar 6;10(7):2315-2321. doi: 10.12998/wjcc.v10.i7.2315.
BACKGROUND
Granulocytic sarcoma (GS) is a rare malignant tumor, and relapse is even rarer in the breast and dorsal spine following allogeneic hematopoietic stem cell transplantation. Currently, a standard treatment regimen is not available.
CASE SUMMARY
A rare case of GS of the right breast and dorsal spine after complete remission of acute myelogenous leukemia is reported here. A 55-year-old female patient presented with a palpable, growing, painless lump as well as worsening dorsal compressive myelopathy. She had a history of acute myelomonocytic leukemia (AML M4) and achieved complete remission after chemotherapy following allogeneic hematopoietic stem cell transplantation. Imaging examinations showed the breast lump and C7-T1 epidural masses suspected of malignancy. Histologic results were compatible with GS in both the right breast and dorsal spine, which were considered extramedullary relapse of the AML treated 4 years earlier.
CONCLUSION
A rare case of GS relapse following allogeneic hematopoietic stem cell transplantation and guidelines for treatment are discussed.
背景
粒细胞肉瘤（GS）是一种罕见的恶性肿瘤，在异基因造血干细胞移植后，乳腺和胸椎复发更为罕见。目前尚无标准治疗方案。
病例摘要
本文报道了1例急性髓系白血病完全缓解后出现右乳腺和胸椎粒细胞肉瘤的罕见病例。一名55岁女性患者出现可触及的、逐渐增大的无痛性肿块，同时胸椎压迫性脊髓病加重。她有急性粒单核细胞白血病（AML M4）病史，异基因造血干细胞移植后化疗获得完全缓解。影像学检查显示乳腺肿块及C7-T1硬膜外肿块，怀疑为恶性肿瘤。组织学结果显示右乳腺和胸椎均符合粒细胞肉瘤，考虑为4年前治疗的AML髓外复发。
结论
讨论了1例异基因造血干细胞移植后粒细胞肉瘤复发的罕见病例及治疗指南。
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