Tasic Danijela, Radenkovic Sonja, Kocic Gordana, Ilic Marina Deljanin, Ignjatovic Aleksandra
Clinical Centre of Nis, The Clinic of Nephrology, Dr. Zoran Djindjic Boulevard 48, 18000 Nis, Serbia.
Clinical Centre of Nis, The Clinic of Nephrology, Dr. Zoran Djindjic Boulevard 48, 18000 Nis, Serbia ; The University of Nis, Faculty of Medicine, Dr. Zoran Djindjic Boulevard 81, 18000 Nis, Serbia.
Dis Markers. 2015;2015:470589. doi: 10.1155/2015/470589. Epub 2015 Jan 14.
To determine levels of interleukin-8 (IL-8) and plasminogen activator inhibitor-1 (PAI-1) in different cardiorenal syndrome (CRS) modalities and to compare findings to some already investigated direct and indirect parameters of inflammation and atherosclerosis.
Testing involved 114 examinees, divided into control and clinical groups suffering from different modalities and were formed according to the basis of a valid classification for CRS.
C-reactive protein (CRP) was significantly higher in all CRSs in comparison to the control group (P < 0.05). PAI-1 in CRSs was statistically higher than in the control group. IL-8 was increased in all CRSs, and especially in CRS-5, where no significance was found. PAI-1 correlated with IL-8 in all CRSs, with significant value in CRS-2 and CRS-5. Correlation for PAI-1 and high-density lipoproteins (HDL) was found in CRS-4, while IL-8 was found to be related to CRP level in all CRSs, with significance only in CRS-1 (P < 0.001).
C-reactive protein, IL-8, and PAI-1 could be useful for clinical differentiation of chronic modalities of CRSs. Inflammation was the most pronounced in CRS-4. Lipid status parameters could be useful for differentiation of CRSs. Furthermore, HDL in chronic primary kidney diseases and triglycerides and total cholesterol in CRS-5 could be valuable.
测定不同类型心肾综合征（CRS）中白细胞介素 - 8（IL - 8）和纤溶酶原激活物抑制剂 - 1（PAI - 1）的水平，并将结果与一些已研究的炎症和动脉粥样硬化的直接和间接参数进行比较。
测试涉及114名受试者，分为对照组和患有不同类型CRS的临床组，这些组是根据有效的CRS分类标准形成的。
与对照组相比，所有CRS类型中的C反应蛋白（CRP）均显著升高（P < 0.05）。CRS类型中的PAI - 1在统计学上高于对照组。所有CRS类型中IL - 8均升高，尤其是在CRS - 5中，但未发现显著差异。在所有CRS类型中PAI - 1与IL - 8相关，在CRS - 2和CRS - 5中有显著相关性。在CRS - 4中发现PAI - 1与高密度脂蛋白（HDL）相关，而在所有CRS类型中IL - 8均与CRP水平相关，仅在CRS - 1中有显著性（P < 0.001）。
C反应蛋白、IL - 8和PAI - 1可用于CRS慢性类型的临床鉴别。炎症在CRS - 4中最为明显。脂质状态参数可用于CRS的鉴别。此外，慢性原发性肾脏疾病中的HDL以及CRS - 5中的甘油三酯和总胆固醇可能具有重要价值。
