Aoki Tomonori, Nagata Naoyoshi, Sakamoto Kayo, Arai Tomohiro, Niikura Ryota, Shimbo Takuro, Shinozaki Masafumi, Sekine Katsunori, Okubo Hidetaka, Watanabe Kazuhiro, Sakurai Toshiyuki, Yokoi Chizu, Akiyama Junichi, Yanase Mikio, Mizokami Masashi, Noda Mitsuhiko, Uemura Naomi
Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan,
Dig Dis Sci. 2015 Jul;60(7):2104-11. doi: 10.1007/s10620-015-3555-6. Epub 2015 Feb 4.
Visceral fat contributes to insulin resistance and atherosclerosis. We retrospectively investigated whether abdominal fat accumulation, as measured by computed tomography, is a risk of ischemic colitis and related clinical outcomes.
Outpatient-onset ischemic colitis patients (n = 58) and age- and sex-matched controls (n = 58) underwent colonoscopy and computed tomography. Associations between body mass index, visceral adipose tissue area, subcutaneous adipose tissue area, and ischemic colitis were estimated using odds ratios adjusted for hypertension, diabetes mellitus, and dyslipidemia.
In multivariate analysis, ischemic colitis was significantly associated with subcutaneous adipose tissue area (P for trend 0.030) and marginally associated with visceral adipose tissue area (P for trend 0.094), but was not associated with body mass index (P for trend 0.460). The adjusted odds ratios for the highest quartile of subcutaneous and visceral adipose tissue in ischemic colitis were 3.48 (1.06-11.4) and 2.43 (0.74-8.00), respectively, compared with the lowest quartile. When body mass index was considered simultaneously, ischemic colitis remained associated with subcutaneous adipose tissue (P for trend 0.016) and visceral adipose tissue (P for trend 0.077). No significant differences were noted between any of the obesity indices and the distribution type of colitis, blood transfusion requirement, or length of hospital stay.
Abdominal fat accumulation measured by computed tomography, but not body mass index, was associated with outpatient-onset ischemic colitis. Ischemic colitis remained associated with abdominal fat, even when body mass index was simultaneously considered. However, clinical outcomes of ischemic colitis were not associated with abdominal fat accumulation.
内脏脂肪会导致胰岛素抵抗和动脉粥样硬化。我们进行了一项回顾性研究，以探究通过计算机断层扫描测量的腹部脂肪堆积是否是缺血性结肠炎及相关临床结局的风险因素。
门诊发病的缺血性结肠炎患者（n = 58）以及年龄和性别匹配的对照组（n = 58）接受了结肠镜检查和计算机断层扫描。使用针对高血压、糖尿病和血脂异常进行校正的比值比来评估体重指数、内脏脂肪组织面积、皮下脂肪组织面积与缺血性结肠炎之间的关联。
在多变量分析中，缺血性结肠炎与皮下脂肪组织面积显著相关（趋势P值为0.030），与内脏脂肪组织面积呈边缘性相关（趋势P值为0.094），但与体重指数无关（趋势P值为0.460）。与最低四分位数相比，缺血性结肠炎患者皮下和内脏脂肪组织最高四分位数的校正比值比分别为3.48（1.06 - 11.4）和2.43（0.74 - 8.00）。当同时考虑体重指数时，缺血性结肠炎仍与皮下脂肪组织（趋势P值为0.016）和内脏脂肪组织（趋势P值为0.077）相关。在任何肥胖指数与结肠炎的分布类型、输血需求或住院时间之间均未观察到显著差异。
通过计算机断层扫描测量的腹部脂肪堆积而非体重指数与门诊发病的缺血性结肠炎相关。即使同时考虑体重指数，缺血性结肠炎仍与腹部脂肪相关。然而，缺血性结肠炎的临床结局与腹部脂肪堆积无关。
