Hu Yuan-Yuan, Qin Chuan-Qi, Deng Mo-Hong, Niu Yu-Ming, Long Xing
Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China ; Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China.
Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China.
Dis Markers. 2015;2015:763090. doi: 10.1155/2015/763090. Epub 2015 Jan 12.
To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.
Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.
Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28-1.82, P < 0.01, I (2) = 0%; CC versus TT: OR = 2.58, 95% CI = 1.74-3.82, P < 0.01, I (2) = 0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14-1.84, P < 0.01, I (2) = 0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46-4.14, P < 0.01, I(2) = 47.0%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).
This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.
探讨骨形态发生蛋白4（BMP4）基因rs17563多态性与非综合征性唇腭裂（NSCL/P）发病风险之间的关联。
检索四个在线数据库并收集相关出版物。采用比值比（OR）及95%置信区间（CI）评估两者关系；进行发表偏倚、Meta回归及敏感性分析以确保结果的可靠性。
共纳入六项已发表的病例对照研究。总体而言，未发现BMP4基因rs17563多态性与NSCL/P发病风险之间存在显著关联。值得注意的是，分层分析显示不同种族存在显著易感性差异。对于中国人群，BMP4基因rs17563多态性显著增加NSCL/P发病风险（C与T比较：OR = 1.52，95%CI = 1.28 - 1.82，P < 0.01，I² = 0%；CC与TT比较：OR = 2.58，95%CI = 1.74 - 3.82，P < 0.01，I² = 0%；TC + CC与TT比较：OR = 1.45，95%CI = 1.14 - 1.84，P < 0.01，I² = 0%；CC与TT + TC比较：OR = 2.46，95%CI = 1.46 - 4.14，P < 0.01，I² = 47.0%）。相反，在巴西人群中发现该多态性具有显著的保护作用（C与T比较：OR = 0.69，95%CI = 0.50 - 0.96，P = 0.03，I² = 68.5%；TC与TT比较：OR = 0.52，95%CI = 0.40 - 0.68，P < 0.01，I² = 0%；TC + CC与TT比较：OR = 0.52，95%CI = 0.35 - 0.78，P < 0.010，I² = 54.4%）。
该Meta分析表明，基于种族差异，BMP4基因rs17563多态性在NSCL/P发生发展过程中可能发挥不同作用。
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