Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Fetal Pediatr Pathol. 2021 Aug;40(4):305-319. doi: 10.1080/15513815.2019.1707916. Epub 2020 Jan 7.
Although published individual studies have reported associations between BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCLP) risk, the results are conflicting. This meta-analysis was conducted to assess the association based on multiple studies. A comprehensive literature search up to October 1st, 2019 was performed using PubMed, Science Direct, China National Knowledge Infrastructure (CNKI), and Wanfang databases. Fourteen case-control studies with 2,058 NSCLP cases and 2,557 controls were selected. There was no significant association between BMP4 rs17563 polymorphism and risk of NSCLP overall. Subgroup analysis revealed that BMP4 rs17563 polymorphism was associated with NSCLP risk in Chinese and Brazilian populations. This meta-analysis suggests that BMP4 rs17563 polymorphism was not associated with NSCLP risk in overall population. However, BMP4 rs17563 polymorphism may be a risk factor for development of NSCLP in Chinese and Brazilians.
尽管已经发表的个别研究报告了 BMP4 rs17563 多态性与非综合征性唇裂伴或不伴腭裂（NSCLP）风险之间的关联，但结果存在争议。本荟萃分析旨在根据多项研究评估这种关联。 我们使用 PubMed、Science Direct、中国国家知识基础设施（CNKI）和万方数据库对截至 2019 年 10 月 1 日的文献进行了全面检索。 选择了 14 项病例对照研究，共有 2058 例 NSCLP 病例和 2557 例对照。BMP4 rs17563 多态性与 NSCLP 总体风险之间没有显著关联。亚组分析显示，BMP4 rs17563 多态性与中国和巴西人群的 NSCLP 风险相关。 这项荟萃分析表明，BMP4 rs17563 多态性与总体人群的 NSCLP 风险无关。然而，BMP4 rs17563 多态性可能是中国人和巴西人发生 NSCLP 的危险因素。
