Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Facultad de Medicina y Odontologia Universidad de Murcia, Hospital Morales Meseguer, Clinica Odontologic Adv Marques Velez s/n, 30008 Murcia, Spain.
Int J Environ Res Public Health. 2019 Aug 5;16(15):2792. doi: 10.3390/ijerph16152792.
Non-syndromic cleft lip/palate (NSCL/P) has an etiology, including both genetic and environmental factors. Herein, we evaluated the association of rs13041247 and rs11696257 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B () polymorphisms with the risk of NSCL/P in a meta-analysis. The PubMed/Medline, Scopus, Cochrane Library, Web of Science, and HuGE Navigator databases were systematically searched to retrieve relevant articles published up to January 2019. The Newcastle-Ottawa scale was applied for quality evaluation of retrieved articles. The 95% confidence interval (CI) and crude odds ratio (OR) were calculated for each study using the Review Manager 5.3 software to show the association between polymorphisms and risk of NSCL/P. The comprehensive meta-analysis 2.0 software was used to calculate the publication bias. In addition, sensitivity analysis was carried out to show the stability of results. Of 102 articles retrieved from the databases, 10 articles were analyzed in this meta-analysis. Ten articles, including eleven studies reporting rs13041247 polymorphism, included 3082 NSCL/P patients and 4104 controls. Three studies that reported rs11696257 polymorphism involved 845 NSCL/P patients and 927 controls. The rs11696257 polymorphism was not associated with the risk of NSCL/P, but the CC and TC genotypes of rs13041247 polymorphism were associated with the risk of NSCL/P. Nevertheless, the C allele and CC and TC genotypes were associated with a significant decline in the risk of NSCL/P in population-based studies. The results of this meta-analysis demonstrated that the risk of NSCL/P was related to rs13041247 polymorphism, not rs11696257 polymorphism. Well-designed studies are required to assess the interaction of and other genes with environmental factors in different ethnic groups.
非综合征性唇腭裂（NSCL/P）的病因包括遗传和环境因素。在此，我们通过荟萃分析评估了 rs13041247 和 rs11696257 v-maf 肌动蛋白-aponeurotic 纤维肉瘤癌基因同源物 B () 多态性与 NSCL/P 风险的关联。系统检索了 PubMed/Medline、Scopus、Cochrane 图书馆、Web of Science 和 HuGE Navigator 数据库，以检索截至 2019 年 1 月发表的相关文章。应用纽卡斯尔-渥太华量表评估检索文章的质量。使用 Review Manager 5.3 软件计算每个研究的 95%置信区间（CI）和粗比值比（OR），以显示 多态性与 NSCL/P 风险之间的关联。综合荟萃分析 2.0 软件用于计算发表偏倚。此外，进行敏感性分析以显示结果的稳定性。从数据库中检索到 102 篇文章，其中 10 篇文章进行了荟萃分析。10 篇文章包括 11 项研究 rs13041247 多态性，共纳入 3082 例 NSCL/P 患者和 4104 例对照。报道 rs11696257 多态性的 3 项研究共纳入 845 例 NSCL/P 患者和 927 例对照。rs11696257 多态性与 NSCL/P 风险无关，但 rs13041247 多态性的 CC 和 TC 基因型与 NSCL/P 风险相关。然而，在基于人群的研究中，C 等位基因和 CC 和 TC 基因型与 NSCL/P 风险显著降低相关。本荟萃分析结果表明，NSCL/P 的风险与 rs13041247 多态性相关，与 rs11696257 多态性无关。需要设计良好的研究来评估不同种族群体中 与其他基因和环境因素的相互作用。
