肿瘤肾脏病学：对癌症与慢性肾脏病关联的评估
Onco-nephrology: an appraisal of the cancer and chronic kidney disease links.
作者信息
Izzedine Hassan, Perazella Mark A
机构信息
Department of Nephrology, Monceau Park International Clinic, Paris, France.
Department of Nephrology, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Nephrol Dial Transplant. 2015 Dec;30(12):1979-88. doi: 10.1093/ndt/gfu387. Epub 2015 Feb 3.
A bidirectional relationship has been observed for kidney disease and cancer. On the one hand, cancer is an important complication noted in kidney disease as well as a major cause of morbidity and mortality in this group. On the other hand, improved cancer treatment has prolonged survival, but also increased the development of acute and chronic kidney disease. The combination of cancer and kidney disease makes it challenging for clinicians to provide comprehensive and safe therapies for this group of patients. As such, clinicians caring for this group must develop expertise and become competent in the practice of a newly evolving subspecialty of nephrology known as 'onco-nephrology'. This brief narrative review will focus on the cancer risk in patients with underlying kidney disease, the therapies such as erythropoiesis-stimulating agents on cancer progression and other outcomes, and the appropriate dosing of anti-cancer agents in patients with underlying kidney disease.
人们已经观察到肾脏疾病与癌症之间存在双向关系。一方面，癌症是肾脏疾病中一种重要的并发症，也是该群体发病和死亡的主要原因。另一方面，癌症治疗的改善延长了患者的生存期，但也增加了急性和慢性肾脏疾病的发生。癌症与肾脏疾病并存，使得临床医生为这组患者提供全面且安全的治疗颇具挑战性。因此，照顾这组患者的临床医生必须培养专业技能，并在一个新兴的肾脏病亚专业——“肿瘤肾脏病学”的实践中具备胜任能力。这篇简短的叙述性综述将聚焦于患有基础肾脏疾病患者的癌症风险、促红细胞生成素等治疗方法对癌症进展及其他结局的影响，以及患有基础肾脏疾病患者的抗癌药物合适剂量。
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