Schmidl Doreen, Witkowska Katarzyna Jadwiga, Kaya Semira, Baar Carina, Faatz Henrik, Nepp Johannes, Unterhuber Angelika, Werkmeister René Marcel, Garhofer Gerhard, Schmetterer Leopold
Department of Clinical Pharmacology, Medical University of Vienna, Austria Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Invest Ophthalmol Vis Sci. 2015 Feb 3;56(3):1467-72. doi: 10.1167/iovs.14-15814.
The aim of the present study was to evaluate the association between symptoms and different clinical signs in patients with dry-eye syndrome (DES).
Fifty-two patients with DES were included in the present cross-sectional study. For assessment of symptoms, the Ocular Surface Disease Index (OSDI) was used. Clinical parameters included measurement of tear break up time (BUT), corneal fluorescein staining, tear osmolarity, and ocular scattering index (OSI). Tear film thickness (TFT) was assessed using a custom-built optical coherence tomography (OCT) system with an axial resolution of 1.2 μm. In addition, impression cytology was performed. Correlation coefficients were calculated using linear regression analysis.
The mean OSDI in the present study population was 28.9 ± 17.6, the mean TFT was 4.1 ± 1.3 μm. A significant negative correlation was found between OSDI and TFT (r = -0.34, P = 0.01). Tear film thickness correlated positively with BUT (r = 0.35, P = 0.01), but with no other signs of DES. No association was found between OSDI and the other evaluated signs.
The study population mainly comprised of patients with mild to moderate DES. Tear film thickness as measured with a custom-built OCT device correlated with subjective symptoms in these patients. In agreement with previous data, the association between other signs and symptoms was weak in the present study. Measurement of TFT with OCT may become a valuable tool in the management of DES patients. (ClinicalTrials.gov number, NCT01753687.)
本研究旨在评估干眼综合征（DES）患者症状与不同临床体征之间的关联。
本横断面研究纳入了52例DES患者。使用眼表疾病指数（OSDI）评估症状。临床参数包括泪膜破裂时间（BUT）测量、角膜荧光素染色、泪液渗透压和眼散射指数（OSI）。使用轴向分辨率为1.2μm的定制光学相干断层扫描（OCT）系统评估泪膜厚度（TFT）。此外，还进行了印迹细胞学检查。使用线性回归分析计算相关系数。
本研究人群的平均OSDI为28.9±17.6，平均TFT为4.1±1.3μm。发现OSDI与TFT之间存在显著负相关（r = -0.34，P = 0.01）。泪膜厚度与BUT呈正相关（r = 0.35，P = 0.01），但与DES的其他体征无关。未发现OSDI与其他评估体征之间存在关联。
研究人群主要由轻度至中度DES患者组成。使用定制OCT设备测量的泪膜厚度与这些患者的主观症状相关。与先前数据一致，本研究中其他体征与症状之间的关联较弱。使用OCT测量TFT可能成为管理DES患者的有价值工具。（ClinicalTrials.gov编号，NCT01753687。）
