Harrabi Hanen, Kergoat Marie-Jeanne, Rousseau Jacqueline, Boisjoly Hélène, Schmaltz Heidi, Moghadaszadeh Solmaz, Roy-Gagnon Marie-Hélène, Freeman Ellen E
Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montreal, Canada.
Centre de Recherche, Institut universitaire de gériatrie de Montréal, Montreal, Canada.
Invest Ophthalmol Vis Sci. 2015 Feb 3;56(2):1217-21. doi: 10.1167/iovs.14-15370.
To determine whether people with age-related eye disease have lower cognitive scores than people with healthy vision.
A hospital-based cross-sectional study was performed in which 420 people aged 65 and older from the ophthalmology clinics at Maisonneuve-Rosemont Hospital (Montreal, Canada) were recruited who had age-related macular degeneration (AMD), Fuch's corneal dystrophy, or glaucoma. Patients with AMD and Fuchs had to have visual acuity in the better eye of worse than 20/40 while patients with glaucoma had to have visual field in their worse eye of at least -4 dB. Controls, recruited from the same clinics, did not have significant vision loss. Cognitive status was measured using the Mini-Mental State Exam Blind Version (range, 0-22) which excludes eight items that rely on vision. Linear regression with bootstrapped standard errors was used to adjust for demographic and medical factors.
People with AMD, Fuch's corneal dystrophy, and glaucoma had lower cognitive scores, on average, than controls (P < 0.05). These relationships remained statistically significant after adjusting for factors such as age, sex, race, education, living alone, systemic comorbidities, and lens opacity.
People with vision loss due to three different age-related eye diseases had lower cognitive scores. Reasons for this should be explored using longitudinal studies and a full battery of cognitive tests that do not rely on vision.
确定患有年龄相关性眼病的人群认知得分是否低于视力正常的人群。
开展了一项基于医院的横断面研究，从加拿大蒙特利尔市迈松纳夫-罗斯蒙特医院眼科诊所招募了420名65岁及以上患有年龄相关性黄斑变性（AMD）、富克斯角膜营养不良或青光眼的患者。AMD和富克斯角膜营养不良患者较好眼的视力须低于20/40，青光眼患者较差眼的视野须至少为-4 dB。从同一诊所招募的对照组没有明显的视力丧失。使用排除了八项依赖视力项目的简易精神状态检查表盲文版（范围为0-22）来测量认知状态。采用带有自抽样标准误的线性回归来调整人口统计学和医学因素。
平均而言，患有AMD、富克斯角膜营养不良和青光眼的人群认知得分低于对照组（P<0.05）。在调整年龄、性别、种族、教育程度、独居、全身合并症和晶状体混浊等因素后，这些关系仍具有统计学意义。
因三种不同的年龄相关性眼病而视力丧失的人群认知得分较低。应通过纵向研究和一系列不依赖视力的全面认知测试来探究其原因。
