Read Scott A, Collins Michael J, Vincent Stephen J, Alonso-Caneiro David
Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Retina. 2015 Jun;35(6):1223-33. doi: 10.1097/IAE.0000000000000464.
To examine macular retinal thickness and retinal layer thickness with spectral domain optical coherence tomography in a population of children with normal ocular health and minimal refractive errors.
High-resolution macular optical coherence tomography scans from 196 children aged 4 years to 12 years (mean age: 8 ± 2 years), were analyzed to determine total retinal thickness and thickness of 6 different retinal layers across the central 5 mm of the posterior pole. Automated segmentation with manual correction was used to derive retinal thickness values.
The mean total retinal thickness in the central 1-mm foveal zone was 255 ± 16 μm, and this increased significantly with age (mean increase of 1.8 μm per year) in childhood (P < 0.001). Age-related increases in thickness of some retinal layers were also observed, with changes of the highest statistical significance found in the outer retinal layers in the central foveal region (P < 0.01). Significant topographical variations in thickness of each of the retinal layers were also observed (P < 0.001).
Small magnitude, statistically significant increases in total retinal thickness and retinal layer thickness occur from early childhood to adolescence. The most prominent changes seem to occur in the outer retinal layers of the central fovea.
利用光谱域光学相干断层扫描技术，检测眼部健康正常且屈光不正程度极小的儿童群体的黄斑视网膜厚度和视网膜各层厚度。
对196名年龄在4岁至12岁（平均年龄：8±2岁）的儿童进行高分辨率黄斑光学相干断层扫描，分析后极部中心5毫米范围内的视网膜总厚度以及6个不同视网膜层的厚度。采用自动分割并手动校正的方法得出视网膜厚度值。
中央1毫米黄斑区的平均视网膜总厚度为255±16微米，在儿童期，该厚度随年龄显著增加（每年平均增加1.8微米）（P<0.001）。还观察到一些视网膜层厚度随年龄增长而增加，其中中央黄斑区外层视网膜层的变化具有最高的统计学意义（P<0.01）。各视网膜层厚度在地形上也存在显著差异（P<0.001）。
从幼儿期到青春期，视网膜总厚度和视网膜层厚度出现了幅度较小但具有统计学意义的增加。最显著的变化似乎发生在中央黄斑区的外层视网膜层。
