Regional Distribution of Choroidal Thickness and Diurnal Variation in Choroidal Thickness and Axial Length in Young Adults.

PURPOSE

To examine the regional distribution of choroidal thickness (ChT) and the diurnal variation in ChT and axial length (AL) over a wide range of myopic refractive error.

METHODS

ChT was measured in thirty-four healthy young adults (age mean ± SD: 25.2 ± 2.8, range: 18-35 years) using spectral-domain optical coherence tomography and AL using an IOL-Master 500. Participants were divided into three refractive groups: emmetropes, myopes, and high myopes. We evaluated ChT in macular (foveal, parafovea, and perifovea) and peripheral regions (6-mm from the foveal pit) in four quadrants (superior, temporal, inferior, and nasal). To assess the diurnal variation, three measurement sessions of ChT and AL were taken at 8 AM, 12 PM, 4 PM.

RESULTS

ChT thins progressively towards the periphery. Superior and nasal quadrants exhibited the thickest (277 ± 73 µm) and thinnest (218 ± 89 µm) choroid, respectively. Higher myopic eyes showed an overall thinner choroid (237 ± 48 µm) compared to myopic eyes (264 ± 78 µm) (P < 0.05). Higher myopes exhibited a significant choroidal thinning in all quadrants except in the temporal quadrant (all p < 0.05). Both ChT and AL underwent a significant diurnal variation (p < 0.05). The ChT and AL diurnal variation amplitudes in higher myopes were significantly reduced (ChT: 14.6 ± 11, AL: 14.5 ± 13 µm), compared to those in emmetropes (ChT: 21.4 ± 15, AL: 21.3 ± 8.5 µm) and myopes (ChT: 19 ± 17, AL: 19 ± 9.7 µm). Diurnal variation amplitude in ChT did not differ significantly across quadrants and choroidal eccentricity regions (p > 0.05).

CONCLUSION

ChT distribution varies based on quadrant and eccentricity; superior choroid exhibited the thickest, and nasal showed the thinnest choroid. Higher myopes experience a reduced diurnal variation in ChT and AL.