陆生动物中的新型肽化学：来自发光蚯蚓Fridericia heliota的天然荧光素类似物。
Novel peptide chemistry in terrestrial animals: natural luciferin analogues from the bioluminescent earthworm Fridericia heliota.
作者信息
Dubinnyi Maxim A, Tsarkova Aleksandra S, Petushkov Valentin N, Kaskova Zinaida M, Rodionova Natalja S, Kovalchuk Sergey I, Ziganshin Rustam H, Baranov Mikhail S, Mineev Konstantin S, Yampolsky Ilia V
机构信息
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
出版信息
Chemistry. 2015 Mar 2;21(10):3942-7. doi: 10.1002/chem.201406498. Epub 2015 Feb 4.
We report isolation and structure elucidation of AsLn5, AsLn7, AsLn11 and AsLn12: novel luciferin analogs from the bioluminescent earthworm Fridericia heliota. They were found to be highly unusual modified peptides, comprising either of the two tyrosine-derived chromophores, CompX or CompY and a set of amino acids, including threonine, gamma-aminobutyric acid, homoarginine, and unsymmetrical N,N-dimethylarginine. These natural compounds represent a unique peptide chemistry found in terrestrial animals and rise novel questions concerning their biosynthetic origin.
我们报道了从发光蚯蚓弗里德里西亚太阳虫中分离并阐明了AsLn5、AsLn7、AsLn11和AsLn12这几种新型荧光素类似物的结构。它们被发现是非常特殊的修饰肽，由两种酪氨酸衍生的发色团CompX或CompY中的一种以及一组氨基酸组成，这些氨基酸包括苏氨酸、γ-氨基丁酸、高精氨酸和不对称N,N-二甲基精氨酸。这些天然化合物代表了陆生动物中发现的一种独特的肽化学，并引发了关于其生物合成起源的新问题。
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