Fontela Paula Caitano, Winkelmann Eliane Roseli, Ott Joice Nedel, Uggeri Douglas Prestes
Regional University of the Northwest of Rio Grande dos Sul State, Ijuí, RS, Brazil.
Regional University of the Northwest of Rio Grande do Sul State, Ijuí, RS, Brazil.
Rev Assoc Med Bras (1992). 2014 Nov-Dec;60(6):531-7. doi: 10.1590/1806-9282.60.06.010.
to estimate the glomerular filtration using the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, and serum creatinine in the screening of reduced renal function in patients with type two diabetes (T2DM) enrolled in the Family Health Strategy (ESF, Brazilian federal health-care program).
a cross-sectional descriptive and analytical study was conducted. The protocol consisted of sociodemographics, physical examination and biochemical tests. Renal function was analyzed through serum creatinine and glomerular filtration rate (GFR) estimated according to the CG, MDRD and CKD-EPI equations, available on the websites of the Brazilian Nephrology Society (SBN) and the (NKF).
146 patients aged 60.9 ± 8.9 years were evaluated; 64.4% were women. The prevalence of serum creatinine >1.2 mg/dL was 18.5% and GFR < 60 mL/min/1.73 m2 totaled 25.3, 36.3 and 34.2% when evaluated by the equations CG, MDRD and CKD-EPI, respectively. Diabetic patients with reduced renal function were older, had long-term T2DM diagnosis, higher systolic blood pressure and higher levels of fasting glucose, compared to diabetics with normal renal function. Creatinine showed strong negative correlation with the glomerular filtration rate estimated using CG, MDRD and CKD-EPI (-0.64, -0.87, -0.89) equations, respectively.
the prevalence of individuals with reduced renal function based on serum creatinine was lower, reinforcing the need to follow the recommendations of the SBN and the National Kidney Disease Education Program (NKDEP) in estimating the value of the glomerular filtration rate as a complement to the results of serum creatinine to better assess the renal function of patients.
使用考克饶夫-高尔特（CG）公式、肾脏病饮食改良（MDRD）公式和慢性肾脏病流行病学合作组织（CKD-EPI）公式估算肾小球滤过率，并评估血清肌酐在巴西联邦医疗保健计划“家庭健康战略”（ESF）中登记的2型糖尿病（T2DM）患者肾功能减退筛查中的作用。
开展了一项横断面描述性和分析性研究。研究方案包括社会人口统计学、体格检查和生化检测。通过血清肌酐和根据CG、MDRD和CKD-EPI公式估算的肾小球滤过率（GFR）分析肾功能，这些公式可在巴西肾脏病学会（SBN）和美国国家肾脏基金会（NKF）的网站上获取。
对146名年龄为60.9±8.9岁的患者进行了评估；64.4%为女性。血清肌酐>1.2mg/dL的患病率为18.5%，当分别采用CG、MDRD和CKD-EPI公式评估时，GFR<60mL/min/1.73m²的比例分别为25.3%、36.3%和34.2%。与肾功能正常的糖尿病患者相比，肾功能减退的糖尿病患者年龄更大，T2DM诊断时间更长，收缩压更高，空腹血糖水平更高。肌酐与使用CG、MDRD和CKD-EPI公式估算的肾小球滤过率分别呈强负相关（-0.64、-0.87、-0.89）。
基于血清肌酐的肾功能减退个体患病率较低，这进一步表明需要遵循SBN和美国国家肾脏疾病教育计划（NKDEP）的建议，估算肾小球滤过率的值，以补充血清肌酐结果，从而更好地评估患者的肾功能。
