Li Hao, Zhang You-yi
Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Dec 18;46(6):1001-4.
Sympathetic nervous system is excessively activated under strong stress, which leads to a significant rise of plasma catecholamine concentration, then activates the 13-adrenoceptors ( 13-ARs) in the heart and mediates the development of cardiac remodeling and heart failure. Meanwhile, chronic 13-ARs activation has been proved to be involved in cardiac sterile inflammation by mediating the synthesis and secretion of cytokines, which subsequently mediates cardiac fibrosis and dysfunction. This review summarizes a number of important proinflammatory cytokines involved in the process of cardiac pathological remodeling under chronic adrenergic stimulation and the application of neutralizing antibodies on specifically targeting cytokines in the treatment of cardiovascular diseases.
在强烈应激下，交感神经系统过度激活，导致血浆儿茶酚胺浓度显著升高，进而激活心脏中的β-肾上腺素能受体（β-ARs），介导心脏重塑和心力衰竭的发展。同时，慢性β-ARs激活已被证明通过介导细胞因子的合成和分泌参与心脏无菌性炎症，随后介导心脏纤维化和功能障碍。本文综述了慢性肾上腺素能刺激下参与心脏病理重塑过程的一些重要促炎细胞因子，以及中和抗体在心血管疾病治疗中特异性靶向细胞因子的应用。
