Beeman R W, Stuart J J, Haas M S, Denell R E
USDA, ARS, U.S. Grain Marketing Research Laboratory, Manhattan, Kansas 66502.
Dev Biol. 1989 May;133(1):196-209. doi: 10.1016/0012-1606(89)90311-4.
Our laboratories have undertaken both genetic and molecular studies of the homeotic gene complex (HOM-C) of the beetle Tribolium castaneum, and this paper discusses results from our genetic analyses. We describe here the adult phenotypes and complementation behavior of over 50 new mutations. Many of these homeotic phenotypes resemble those of Drosophila melanogaster, but few precisely parallel the segmental transformations seen in this fly. Analysis of putative loss-of-function mutations affecting the head and thorax suggests that the maxillopedia and Cephalothorax genes most closely resemble proboscipedia and Sex combs reduced of Drosophila. In the abdomen, putative loss-of-function alleles of Abdominal affect a domain corresponding to those of the combined abdominal-A and Abdominal-B genes of Drosophila. In contrast to the situation in flies, Abdominal loss-of-function variants in Tribolium cause anteriorward transformations in A3-A5a, but posteriorward transformations in A5p-A7. The implications of the differences in developmental strategies evolved in Tribolium vs Drosophila are discussed.
我们的实验室对赤拟谷盗的同源异型基因复合体（HOM-C）进行了遗传学和分子学研究，本文讨论了我们遗传学分析的结果。我们在此描述了50多个新突变的成虫表型和互补行为。这些同源异型表型中的许多与黑腹果蝇的相似，但很少与该果蝇中观察到的节段转化完全平行。对影响头部和胸部的假定功能丧失突变的分析表明，下颚足节和头胸部基因与果蝇的触须足节基因和性梳减少基因最为相似。在腹部，腹部基因的假定功能丧失等位基因影响一个与果蝇腹部-A和腹部-B基因组合相对应的区域。与果蝇的情况不同，赤拟谷盗中腹部基因功能丧失变体在A3-A5a中导致向前转化，但在A5p-A7中导致向后转化。文中讨论了赤拟谷盗与果蝇在进化过程中发育策略差异的影响。
