二甲苯胺在体外增强松果体N - 乙酰转移酶活性。

Xylamine enhances pineal gland N-acetyltransferase activity in vitro.

Haak K A, Torres G, Garvey P L, Bronstein D M, Cho A K, Lytle L D

Department of Psychology, University of California, Santa Barbara 93106.

Gen Pharmacol. 1989;20(1):77-80. doi: 10.1016/0306-3623(89)90064-5.

Abstract

The action of N-2'-chloroethyl-N-ethyl-2-methyl benzylamine (xylamine) on rat pineal gland sympathetic innervation was examined. 2. This alkylating agent caused a concentration-dependent increase in pineal gland N-acetyltransferase (NAT) activity in neurologically intact pineal glands that was suppressed in glands previously subjected to bilateral superior cervical ganglionectomy. 3. Xylamine-induced elevations in NAT activity were attenuated by beta-noradrenergic antagonist drugs but not by alpha-noradrenergic antagonist drugs. 4. Since pineal gland uptake of radiolabelled norepinephrine (NE) was impaired by xylamine, the drug may increase pineal gland NAT activity by inhibiting NE reuptake into the presynaptic nerve terminal, thereby increasing the amount of the neurotransmitter available to stimulate pinealocyte beta-noradrenoceptors.

摘要

研究了N-2'-氯乙基-N-乙基-2-甲基苄胺（二甲胺）对大鼠松果体交感神经支配的作用。2. 这种烷基化剂使神经功能完整的松果体中松果体N-乙酰转移酶（NAT）活性呈浓度依赖性增加，而在先前接受双侧颈上神经节切除术的松果体中这种增加受到抑制。3. 二甲胺诱导的NAT活性升高被β-去甲肾上腺素能拮抗剂药物减弱，但未被α-去甲肾上腺素能拮抗剂药物减弱。4. 由于二甲胺损害了松果体对放射性标记去甲肾上腺素（NE）的摄取，该药物可能通过抑制NE重新摄取到突触前神经末梢来增加松果体NAT活性，从而增加可用于刺激松果体细胞β-去甲肾上腺素能受体的神经递质数量。