National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
Nanoscale. 2015 Mar 7;7(9):4020-30. doi: 10.1039/c4nr07027e.
Combination chemotherapy has been proven promising for cancer treatment, but unsatisfactory therapeutic data and increased side effects slow down the development in the clinic. In this study, we develop an effective approach to co-encapsulate a hydrophilic-hydrophobic chemotherapeutic drug pair (paclitaxel and doxorubicin) into magnetic O-carboxymethyl-chitosan nanoparticles. To endow them with the ability of programmed delivery, these carriers are further camouflaged with an Arg-Gly-Asp anchored erythrocyte membrane. Compared with the traditional polyethylene glycol coating method, this biomimetic decoration strategy is demonstrated to be superior in prolonging circulation time, improving tumor accumulation, facilitating tumor uptake, and tuning intracellular fate. These outstanding properties enable the as-designed nanodevice to exhibit greater tumor growth inhibition ability and much lower side effects than the combined use of commercial formulations.
联合化疗已被证明在癌症治疗方面具有广阔的前景，但不尽如人意的治疗数据和增加的副作用减缓了其在临床上的发展。在本研究中，我们开发了一种将亲水性-疏水性化疗药物对（紫杉醇和阿霉素）共包封到磁性 O-羧甲基壳聚糖纳米颗粒中的有效方法。为了赋予它们程序化递药的能力，这些载体进一步用 Arg-Gly-Asp 锚定的红细胞膜伪装。与传统的聚乙二醇涂层方法相比，这种仿生修饰策略在延长循环时间、提高肿瘤积累、促进肿瘤摄取和调节细胞内命运方面表现出优越性。这些卓越的性能使设计的纳米器件表现出比商业制剂联合使用更强的肿瘤生长抑制能力和更低的副作用。
