Okamoto Shin, Iida Osamu, Nakamura Masato, Yamauchi Yasutaka, Fukunaga Masashi, Yokoi Yoshiaki, Soga Yoshimitsu, Zen Kan, Hirano Keisuke, Suematsu Nobuhiro, Suzuki Kenji, Shintani Yoshiaki, Miyashita Yusuke, Urasawa Kazushi, Kitano Ikuro, Yamaoka Terutoshi, Ohura Norihiko, Hamasaki Toshimitsu, Uematsu Masaaki, Nanto Shinsuke
Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan
Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan.
Angiology. 2015 Oct;66(9):862-6. doi: 10.1177/0003319715569907. Epub 2015 Feb 4.
Although skin perfusion pressure (SPP) is widely used clinically to predict probability of wound healing, correlation between clinical outcomes and SPP has not been systematically studied.
This subanalysis of the prospective multicenter OLIVE registry of patients who received infrainguinal endovascular therapy (EVT) for critical limb ischemia (CLI) assessed the association between clinical outcomes and postoperative SPP in 211 consecutive patients. Logistic regression analysis was performed, with amputation-free survival (AFS), modified major adverse limb events (MALEs), and complete wound healing as dependent variables and postprocedural SPP as independent variable.
Pre- and postprocedural SPP was 28 ± 11 and 46 ± 18 mm Hg, respectively. In logistic regression analysis, postprocedural SPP correlated with 1-year AFS (P = .018), modified MALEs (P < .001), and wound healing (P = .022).
Postprocedural SPP correlates with clinical outcomes after EVT for patients with CLI.
尽管皮肤灌注压（SPP）在临床上被广泛用于预测伤口愈合的可能性，但临床结果与SPP之间的相关性尚未得到系统研究。
这项对接受下肢缺血性疾病（CLI）的腹股沟下血管内治疗（EVT）的患者进行的前瞻性多中心OLIVE注册研究的亚分析，评估了211例连续患者的临床结果与术后SPP之间的关联。进行了逻辑回归分析，将无截肢生存期（AFS）、改良的主要肢体不良事件（MALEs）和伤口完全愈合作为因变量，将术后SPP作为自变量。
术前和术后SPP分别为28±11和46±18 mmHg。在逻辑回归分析中，术后SPP与1年AFS（P = 0.018）、改良的MALEs（P < 0.001）和伤口愈合（P = 0.022）相关。
对于CLI患者，术后SPP与EVT后的临床结果相关。
