Li Dandan, Cheng Junjie, Li Wanghong, Ma Wei, Zhou Xu, Zheng Lianwen, Li Chunjin
The Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China.
College of Animal Sciences, Jilin University, 5333 Xi'an Avenue, Changchun, Jilin Province, 130062, China.
Iran J Reprod Med. 2015 Jan;13(1):35-40.
Progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. Investigations have showed that polymorphism of progesterone receptor (PGR) is associated with some diseases.
To analyze the potential relationship between male infertility and the +331G/A and progins polymorphisms of PGR gene.
The cross-sectional study was carried out at the Department of Male Reproduction, Reproductive Medical Center, the Second Hospital of Jilin University. The restriction fragment length polymorphism (RFLP) technique was used to detect gene point mutations. Of the 145 semen samples analyzed, 35 were asthenozoospermic, 50 were oligoasthenozoospermic, 21 were azoospermic, 11 were teratozoospermic and 28 were from fertile male subjects.
Statistical analyses revealed that the genotypes of the +331G/A polymorphisms were in Hardy-Weinberg equilibrium in both the fertile ((2)=0, p=0.534) and oligospermic groups ((2)=0.021, p=0.537). Similarly, the genotypes of the progins polymorphisms were also in Hardy-Weinberg equilibrium in both the fertile ((2)=0, p=1) and oligospermic groups ((2)=0.005, p=1).
Our results indicated that polymorphisms of the +331G/A and progins of the PGR gene are unrelated to male infertility, at least in a Chinese population.
有研究表明孕酮有助于精子发生的调节并促进有活力精子的产生。调查显示孕酮受体（PGR）的多态性与某些疾病有关。
分析男性不育与PGR基因+331G/A和孕激素诱导基因（progins）多态性之间的潜在关系。
本横断面研究在吉林大学第二医院生殖医学中心男科进行。采用限制性片段长度多态性（RFLP）技术检测基因点突变。在分析的145份精液样本中，35份为弱精子症，50份为少弱精子症，21份为无精子症，11份为畸形精子症，28份来自生育力正常的男性受试者。
统计分析显示，+331G/A多态性的基因型在生育力正常组（χ²=0，p=0.534）和少精子症组（χ²=0.021，p=0.537）中均处于哈迪-温伯格平衡。同样，孕激素诱导基因多态性的基因型在生育力正常组（χ²=0，p=1）和少精子症组（χ²=0.005，p=1）中也处于哈迪-温伯格平衡。
我们的结果表明，PGR基因的+331G/A和孕激素诱导基因多态性与男性不育无关，至少在中国人中如此。
