Mazaheri-Khameneh Ramin, Sarrafzadeh-Rezaei Farshid, Asri-Rezaei Siamak, Dalir-Naghadeh Bahram
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Vet Res Forum. 2012 Spring;3(2):103-9.
This prospective study aimed to compare the intraosseous (IO) and intravenous (IV) effects of propofol on selected blood parameters and physiological variables during general anesthesia in rabbits. Thirty New Zealand White rabbits were studied. Six rabbits received IV propofol (group 1) and another 6 rabbits, were injected propofol intraosseously (Group 2) for 30 minutes (experimental groups). Rabbits of the third and fourth groups received IV and IO normal saline at the same volume given to the experimental groups, respectively. In the fifth group IO cannulation was performed but neither propofol nor normal saline were administered. Blood profiles were assayed before induction and after recovery of anesthesia. Heart and respiratory rates, rectal temperature, saturation of peripheral oxygen and mean arterial blood pressure were recorded. Heart rate increased significantly 1 to 5 minutes after induction of anesthesia in experimental groups (P < 0.05). Although mean arterial blood pressure decreased significantly from baseline, values remained above 60 mm Hg (P < 0.05). Respiratory rate decreased significantly in experimental groups, but remained higher in group 2 (P < 0.05). The lymphocyte count decreased significantly in group 1 (P < 0.05). The concentration of alkaline phosphatase in all rabbits, aspartate aminotransferase and gamma-glutamyl transferase in the first group and gamma-glutamyl transferase in the third group increased significantly (P < 0.05). Total bilirubin decreased significantly in group 2 (P < 0.05). All measured values remained within normal limits. Based on the least significant physiological, hematological and biochemical effects, the IO injection of propofol appears to be safe and suitable method of anesthesia in rabbits with limited vascular access.
这项前瞻性研究旨在比较异丙酚在兔全身麻醉期间对选定血液参数和生理变量的骨内（IO）和静脉内（IV）作用。研究了30只新西兰白兔。6只兔子接受静脉注射异丙酚（第1组），另外6只兔子接受骨内注射异丙酚（第2组），持续30分钟（实验组）。第三组和第四组的兔子分别接受与实验组相同体积的静脉和骨内生理盐水注射。第五组进行了骨内插管，但未给予异丙酚或生理盐水。在麻醉诱导前和恢复后测定血液指标。记录心率、呼吸频率、直肠温度、外周血氧饱和度和平均动脉血压。实验组在麻醉诱导后1至5分钟心率显著增加（P<0.05）。虽然平均动脉血压较基线显著降低，但仍高于60 mmHg（P<0.05）。实验组呼吸频率显著降低，但第2组仍较高（P<0.05）。第1组淋巴细胞计数显著降低（P<0.05）。所有兔子的碱性磷酸酶浓度、第1组的天冬氨酸转氨酶和γ-谷氨酰转移酶以及第3组的γ-谷氨酰转移酶均显著升高（P<0.05）。第2组总胆红素显著降低（P<0.05）。所有测量值均保持在正常范围内。基于最不显著的生理、血液学和生化效应，对于血管通路有限的兔子，骨内注射异丙酚似乎是一种安全且合适的麻醉方法。
