Sharma Kopal, Sharma Amit, Singh Vikas, Pilania Dinesh, Sharma Yogesh Kumar
Senior Demonstrator, Department of Pharmacology, Mahatma Gandhi Medical College & Hospital , Jaipur, India .
Reader, Department of Oral & Maxillofacial Surgery, Rajasthan Dental College , Jaipur, India .
J Clin Diagn Res. 2014 Dec;8(12):ZC49-52. doi: 10.7860/JCDR/2014/10273.5294. Epub 2014 Dec 5.
There is a growing concern about ever-burgeoning list of irrational fixed dose combinations (FDCs) which have flooded pharmaceutical market recently in India. Till date no structured study has evaluated the level of understanding among the dental clinicians and residents about these concepts. The present study is designed to fulfil that lacuna.
To evaluate the knowledge, attitude and practice, regarding the use of FDCs by the dental residents and dental clinicians in a tertiary care teaching dental hospital.
The present study was carried out among postgraduate students and dental clinicians working at Rajasthan Dental College, a tertiary care teaching dental hospital, in Jaipur, India. Sixty residents and 77 dental clinicians from the departments of Orthodontics, Prosthodontics, Oral Medicine, Periodontology, Conservative Dentistry & Endodontics, Oral & Maxillofacial Surgery, Pedodontics who gave their informed consent were enrolled. A prevalidated questionnaire regarding knowledge, attitude and prescribing practice of fixed dose combinations was filled up. Data was analysed with suitable statistical tests.
Out of the 60 residents and 77 dental clinicians recruited for the study, none of them were aware about all of the advantages and disadvantages of FDCs. On an average, only 47% of residents and 61% dental clinicians were aware of FDC included in WHO Essential Medicines List (EML). Only 47% residents and 58% dental clinicians could recall a single banned FDC in India. Common sources of information about FDCs were Monthly Index of Medical Specialities (MIMS), medical representatives and internet. The most commonly prescribed irrational FDC was diclofenac + paracetamol combination, 42% residents and 41% dental clinicians and residents believed that regular Continuous Medical Education (CMEs) stressing upon rational use of medicine could reduce the magnitude of this problem.
It is the need of the hour to reduce the magnitude of this problem by sensitizing dental residents and prescribers regarding the efficacy, safety, suitability, rationality and cost benefit of FDCs available for patient use.
人们越来越关注印度近期充斥着药品市场的不断增加的不合理固定剂量复方制剂（FDC）清单。迄今为止，尚无结构化研究评估牙科临床医生和住院医生对这些概念的理解程度。本研究旨在填补这一空白。
评估三级护理教学牙科医院中牙科住院医生和牙科临床医生对FDC使用的知识、态度和实践。
本研究在印度斋浦尔的一家三级护理教学牙科医院拉贾斯坦牙科学院工作的研究生和牙科临床医生中进行。来自正畸科、修复科、口腔内科、牙周病科、保守牙科与牙髓病科、口腔颌面外科、儿童牙科等科室的60名住院医生和77名牙科临床医生在签署知情同意书后被纳入研究。填写了一份关于固定剂量复方制剂知识、态度和处方实践的预验证问卷。使用适当的统计测试对数据进行分析。
在招募参加研究的60名住院医生和77名牙科临床医生中，没有人了解FDC的所有优缺点。平均而言，只有47%的住院医生和61%的牙科临床医生知道列入世界卫生组织基本药物清单（EML）的FDC。只有47%的住院医生和58%的牙科临床医生能回忆起印度一种被禁的FDC。关于FDC的常见信息来源是《医学专科月刊索引》（MIMS）、医药代表和互联网。最常处方的不合理FDC是双氯芬酸+对乙酰氨基酚组合，42%的住院医生和41%的牙科临床医生认为，强调合理用药的定期继续医学教育（CME）可以减少这一问题的严重程度。
当务之急是通过提高牙科住院医生和开药者对可供患者使用的FDC的疗效、安全性、适用性、合理性和成本效益的认识，来减少这一问题的严重程度。
