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CCNA1启动子甲基化与恶性肿瘤的相关性：一项荟萃分析介绍

Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction.

作者信息

Yang Bin, Miao Shuai, Zhang Le-Ning, Sun Hong-Bin, Xu Zhe-Nan, Han Chun-Shan

机构信息

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

Department of Geriatrics, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

出版信息

Biomed Res Int. 2015;2015:134027. doi: 10.1155/2015/134027. Epub 2015 Jan 15.

DOI:10.1155/2015/134027
PMID:25654082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4310450/
Abstract

Epigenetic silencing of tumor suppressor genes by promoter methylation plays vital roles in the process of carcinogenesis. The purpose of this meta-analysis was to determine whether the aberrant methylation of cyclin A1 (CCNA1) may be of great significance to human malignant tumors. By searching both English and Chinese language-based electronic databases carefully, we tabulated and analyzed parameters from each study. All human-associated case-control studies were included providing available data for CCNA1 methylation and reporting the adjusted odds ratios (ORs) and 95% confidence intervals (CI) conducted with the use of Version 12.0 STATA software. A total of 10 case-control studies (619 patients with cancers and 292 healthy controls) were included for the following statistical analysis. Pooled OR values from all articles revealed that the frequency of CCNA1 methylation in cancer tissues was significantly higher than those of normal tissues (P < 0.001). Further ethnicity indicated that the frequency of CCNA1 methylation was correlated with the development of malignant tumors among all those included experimental subgroups (all P < 0.05). These data from results indicated a significant connection of CCNA1 methylation with poor progression in human malignant tumors among both Caucasian and Asian populations.

摘要

启动子甲基化导致的肿瘤抑制基因表观遗传沉默在致癌过程中起着至关重要的作用。本荟萃分析的目的是确定细胞周期蛋白A1（CCNA1）的异常甲基化是否对人类恶性肿瘤具有重要意义。通过仔细检索基于英文和中文的电子数据库，我们将每项研究的参数列表并进行分析。纳入所有与人类相关的病例对照研究，这些研究提供了CCNA1甲基化的可用数据，并报告了使用12.0版STATA软件进行的调整优势比（OR）和95%置信区间（CI）。总共纳入10项病例对照研究（619例癌症患者和292例健康对照）进行以下统计分析。所有文章的合并OR值显示，癌组织中CCNA1甲基化的频率显著高于正常组织（P < 0.001）。进一步按种族分析表明，在所有纳入的实验亚组中，CCNA1甲基化频率与恶性肿瘤的发生相关（所有P < 0.05）。这些结果数据表明，在白种人和亚洲人群中，CCNA1甲基化与人类恶性肿瘤的不良进展存在显著关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/dcd3a539f02d/BMRI2015-134027.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/e0cc9531cd3b/BMRI2015-134027.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/d08e28e012ea/BMRI2015-134027.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/02d5f14324a9/BMRI2015-134027.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/f5b4269720b0/BMRI2015-134027.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/57b583dee11c/BMRI2015-134027.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/dcd3a539f02d/BMRI2015-134027.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/e0cc9531cd3b/BMRI2015-134027.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/d08e28e012ea/BMRI2015-134027.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/02d5f14324a9/BMRI2015-134027.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/f5b4269720b0/BMRI2015-134027.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/57b583dee11c/BMRI2015-134027.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49f/4310450/dcd3a539f02d/BMRI2015-134027.006.jpg

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