Han Audrey Yan Yi, Tan Aik Hau, Koh Mariko Siyue
Department of Respiratory and Critical Care Medicine, Singapore General Hospital, 20 College Road, Academia, Singapore 169856.
Biomed Res Int. 2015;2015:257932. doi: 10.1155/2015/257932. Epub 2015 Jan 14.
Objective. Intrathoracic lymphadenopathy (LAD) in patients with Human Immunodeficiency Virus (HIV) infection is common, with wide-ranging diagnoses, from benign to malignant causes. Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) is a relatively new technology with established applications in lung cancer, sarcoidosis, and tuberculosis. We sought to find out whether the addition of EBUS-TBNA to the diagnostic algorithm for LAD in HIV patients will reduce the need for mediastinoscopy. Methods. Retrospective chart review of all EBUS-TBNA procedures performed in our centre from August 2008 to December 2012. Results. 513 patients had EBUS-TBNA performed during this period. We identified nine HIV-infected patients who had LAD of unknown cause and underwent EBUS-TBNA. The procedure reduced the need for mediastinoscopy in eight patients (89%). Conclusions. Potential mediastinoscopies can be avoided by utilising EBUS-TBNA in HIV patients with LAD.
目的。人类免疫缺陷病毒（HIV）感染患者的胸内淋巴结病（LAD）很常见，诊断范围广泛，病因从良性到恶性不等。支气管内超声引导下经支气管针吸活检（EBUS-TBNA）是一项相对较新的技术，在肺癌、结节病和结核病中已有应用。我们试图了解在HIV患者LAD的诊断算法中增加EBUS-TBNA是否会减少纵隔镜检查的需求。方法。对2008年8月至2012年12月在我们中心进行的所有EBUS-TBNA操作进行回顾性病历审查。结果。在此期间，有513例患者接受了EBUS-TBNA检查。我们确定了9例病因不明的LAD且接受了EBUS-TBNA检查的HIV感染患者。该操作减少了8例患者（89%）对纵隔镜检查的需求。结论。对于患有LAD的HIV患者，使用EBUS-TBNA可以避免潜在的纵隔镜检查。
