Collins James J, Anteau Steven E, Swaen Gerard M H, Bodner Kenneth M, Bodnar Catherine M
From the Saginaw Valley State University (Dr Collins), University Center; The Dow Chemical Company (Mr Anteau, Mr Bodner, and Dr Bodnar), Midland, Mich; and Maastricht University (Dr Swaen), the Netherlands.
J Occup Environ Med. 2015 Feb;57(2):159-63. doi: 10.1097/JOM.0000000000000324.
High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic syndrome has been observed at low benzene exposure levels.
We updated a mortality study of workers with benzene exposure examining acute nonlymphocytic leukemia and myelodysplastic syndrome. We calculated standardized mortality ratios with 95% confidence intervals and examined latency and trends for cumulative exposure levels.
All leukemias (standardized mortality ratio = 1.21; 95% confidence interval = 0.74 to 1.97) and acute non-lymphocytic leukemia (standardized mortality ratio = 1.04; 95% confidence interval = 0.34 to 2.44) were at expected levels. We observed one death from myelodysplastic syndrome (standardized mortality ratio = 6.48; 95% confidence interval = 0.17 to 38.15). We observed no trend for cumulative exposure levels.
Our results for all leukemias are consistent with a small increase in risk observed in the lower-exposed subgroups of the Pliofilm study; however, our results are also consistent with no increased risk especially for acute nonlymphocytic leukemia.
高苯暴露与急性非淋巴细胞白血病有关。最近，在低苯暴露水平下也观察到了骨髓增生异常综合征。
我们更新了一项对苯暴露工人的死亡率研究，以调查急性非淋巴细胞白血病和骨髓增生异常综合征。我们计算了标准化死亡比及95%置信区间，并研究了累积暴露水平的潜伏期和趋势。
所有白血病（标准化死亡比=1.21；95%置信区间=0.74至1.97）和急性非淋巴细胞白血病（标准化死亡比=1.04；95%置信区间=0.34至2.44）均处于预期水平。我们观察到1例死于骨髓增生异常综合征（标准化死亡比=6.48；95%置信区间=0.17至38.15）。我们未观察到累积暴露水平的趋势。
我们关于所有白血病的结果与在普利菲姆研究中低暴露亚组观察到的风险略有增加一致；然而，我们的结果也与无风险增加一致，尤其是对于急性非淋巴细胞白血病。
