考虑吸烟因素时厨师患肺癌的风险：来自欧洲、加拿大、新西兰和中国的病例对照研究的汇总分析
Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China.
作者信息
Bigert Carolina, Gustavsson Per, Straif Kurt, Pesch Beate, Brüning Thomas, Kendzia Benjamin, Schüz Joachim, Stücker Isabelle, Guida Florence, Brüske Irene, Wichmann Heinz-Erich, Pesatori Angela C, Landi Maria Teresa, Caporaso Neil, Tse Lap Ah, Yu Ignatius Tak-sun, Siemiatycki Jack, Pintos Javier, Merletti Franco, Mirabelli Dario, Simonato Lorenzo, Jöckel Karl-Heinz, Ahrens Wolfgang, Pohlabeln Hermann, Tardón Adonina, Zaridze David, Field John, 't Mannetje Andrea, Pearce Neil, McLaughlin John, Demers Paul, Szeszenia-Dabrowska Neonila, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Dumitru Rodica Stanescu, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Boffetta Paolo, Forastiere Francesco, Bueno-de-Mesquita Bas, Peters Susan, Vermeulen Roel, Kromhout Hans, Olsson Ann C
机构信息
From the Institute of Environmental Medicine (Drs Bigert and Gustavsson), Karolinska Institutet, Stockholm, Sweden; International Agency for Research on Cancer (Drs Straif, Schüz, and Olsson), Lyon, France; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance-Institute of the Ruhr-Universität Bochum (IPA) (Drs Pesch and Brüning, Mr Kendzia), Germany; Inserm, Centre for Research in Epidemiology and Population Health (CESP) (Drs Stücker and Guida), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France; Université Paris-Sud (Drs Stücker and Guida), UMRS 1018, F-94807, Villejuif, France; Institut für Epidemiologie I (Drs Brüske and Wichmann), Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany; Department of Clinical Sciences and Community Health (Dr Pesatori), Università degli Studi di Milano, Milan, Italy; National Cancer Institute (Drs Landi and Caporaso), Bethesda, MD; Division of Occupational and Environmental Health (Drs Tse and Yu), School of Public Health and Primary Care, The Chinese University of Hong Kong, China; Research Centre of University of Montréal Hospital Centre (Drs Siemiatycki and Pintos), University of Montréal, Canada; Cancer Epidemiology Unit (Drs Merletti and Mirabelli), Department of Medical Sciences, University of Turin, Italy; Department of Environmental Medicine and Public Health (Dr Simonato), University of Padua, Italy; Institute for Medical Informatics (Dr Jöckel), Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany; Bremen Institute for Prevention Research and Social Medicine (Drs Ahrens and Pohlabeln), Bremen, Germany; CIBERESP (Dr Tardón), University of Oviedo, Spain; Russian Cancer Research Centre (Dr Zaridze), Moscow, Russia; Roy Castle Lung Cancer Research Programme, Cancer Research Centre (Dr Field), University of Liverpool, UK; Centre for Public Health Research (Drs Mannetje and Pearce), Massey University, Wellingt
出版信息
J Occup Environ Med. 2015 Feb;57(2):202-9. doi: 10.1097/JOM.0000000000000337.
OBJECTIVES
To investigate the risk of lung cancer among cooks, while controlling for smoking habits.
METHODS
We used data from the SYNERGY project including pooled information on lifetime work histories and smoking habits from 16 case-control studies conducted in Europe, Canada, New Zealand, and China.
RESULTS
Before adjustment for smoking, we observed an increased risk of lung cancer in male cooks, but not in female cooks. After adjusting, there was no increased risk and no significant exposure-response relationship. Nevertheless, subgroup analyses highlighted some possible excess risks of squamous cell carcinoma and small cell carcinoma in female cooks.
CONCLUSIONS
There is evidence that lung cancer risks among cooks may be confounded by smoking. After adjustment, cooks did not experience an increased risk of lung cancer overall. The subgroup analyses showing some excess risks among female cooks require cautious interpretation.
目的
在控制吸烟习惯的情况下，调查厨师患肺癌的风险。
方法
我们使用了SYNERGY项目的数据，其中包括在欧洲、加拿大、新西兰和中国进行的16项病例对照研究中关于终生工作经历和吸烟习惯的汇总信息。
结果
在调整吸烟因素之前，我们观察到男性厨师患肺癌的风险增加，但女性厨师未增加。调整后，没有发现风险增加，也没有显著的暴露-反应关系。然而，亚组分析突出显示了女性厨师患鳞状细胞癌和小细胞癌可能存在一些额外风险。
结论
有证据表明，厨师患肺癌的风险可能受到吸烟的混淆。调整后，厨师总体上患肺癌的风险没有增加。显示女性厨师存在一些额外风险的亚组分析需要谨慎解读。
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