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AIDS virus seeks refuge in B cell follicles.

作者信息

Streeck Hendrik

机构信息

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA, and at the Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

出版信息

Nat Med. 2015 Feb;21(2):111-2. doi: 10.1038/nm.3795.

DOI:10.1038/nm.3795
PMID:25654598
Abstract
摘要

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B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.B细胞滤泡庇护所允许精英控制者中持续存在高效的猿猴免疫缺陷病毒感染。
Nat Med. 2015 Feb;21(2):132-9. doi: 10.1038/nm.3781. Epub 2015 Jan 19.
2
Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.HIV-1 感染治疗研究的新进展:针对 HIV-1 潜伏库。
J Allergy Clin Immunol. 2014 Jul;134(1):12-9. doi: 10.1016/j.jaci.2014.05.026. Epub 2014 Jun 26.
3
Effect of antiretroviral therapy on HIV reservoirs in elite controllers.
Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Manipulation.
通过分子工程化表达 CCR9 和减少操作实现恒河猴 CD8 T 细胞优先归巢小肠和持久性。
J Virol. 2019 Oct 15;93(21). doi: 10.1128/JVI.00896-19. Print 2019 Nov 1.
4
Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence.滤泡树突状细胞内的 Friend 逆转录病毒感染发生于急性感染期,并在病毒持续存在期间得到维持。
mBio. 2019 Feb 19;10(1):e00004-19. doi: 10.1128/mBio.00004-19.
5
CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.通过T细胞工程实现CXCR5依赖性CD8 T细胞进入恒河猴B细胞滤泡
J Virol. 2017 May 12;91(11). doi: 10.1128/JVI.02507-16. Print 2017 Jun 1.
6
Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery.基于腺病毒的免疫接种诱导复杂免疫反应并对逆转录病毒攻击产生强大保护作用,这取决于疫苗接种的顺序。
Retrovirology. 2017 Feb 6;14(1):8. doi: 10.1186/s12977-017-0336-7.
抗逆转录病毒疗法对精英控制者中 HIV 储存库的影响。
J Infect Dis. 2013 Nov 1;208(9):1443-7. doi: 10.1093/infdis/jit306. Epub 2013 Jul 11.
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Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production.滤泡辅助 T 细胞是 HIV-1 感染、复制和产生的主要 CD4 T 细胞群。
J Exp Med. 2013 Jan 14;210(1):143-56. doi: 10.1084/jem.20121932. Epub 2012 Dec 17.
5
Expansion of HIV-specific T follicular helper cells in chronic HIV infection.慢性 HIV 感染中 HIV 特异性滤泡辅助 T 细胞的扩增。
J Clin Invest. 2012 Sep;122(9):3271-80. doi: 10.1172/JCI64314. Epub 2012 Aug 27.
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CD4 T follicular helper cell dynamics during SIV infection.SIV 感染期间 CD4 T 滤泡辅助细胞的动态变化。
J Clin Invest. 2012 Sep;122(9):3281-94. doi: 10.1172/JCI63039. Epub 2012 Aug 27.
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HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.HIV-1 在具有天然 HIV 感染控制能力的患者中继续复制和进化。
J Virol. 2010 Dec;84(24):12971-81. doi: 10.1128/JVI.00387-10. Epub 2010 Oct 6.
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CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles.CXCR5+ CCR7- CD8 T细胞是浸润扁桃体B细胞滤泡的早期效应记忆细胞。
Eur J Immunol. 2007 Dec;37(12):3352-62. doi: 10.1002/eji.200636746.
9
CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue.细胞毒性T淋巴细胞(CTL)无法在淋巴组织中HIV-1复制位点处聚集。
J Immunol. 2007 Jun 1;178(11):6975-83. doi: 10.4049/jimmunol.178.11.6975.
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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.HIV特异性CD8+ T细胞上PD-1表达的上调导致可逆性免疫功能障碍。
Nat Med. 2006 Oct;12(10):1198-202. doi: 10.1038/nm1482. Epub 2006 Aug 20.