Silberman Shuli, Merin Ofer, Fink Daniel, Alshousha Atia, Shachar Sigal, Tauber Rachel, Butnaro Adi, Bitran Daniel
Harefuah. 2014 Dec;153(12):705-8, 754.
The best surgical approach for patients with moderate ischemic mitral regurgitation (IMR) is still undetermined. We examined long term outcomes in patients with moderate IMR undergoing coronary bypass (CABG), and compared outcomes between those undergoing isolated CABG to those undergoing concomitant restrictive annuloplasty.
Between the years 1993-2011, 231 patients with moderate IMR underwent CABG: group 1 (n = 186) underwent isolated CABG, group 2 (n = 15) underwent CABG with concomitant mitral valve annuloplasty. Univariate analysis was used to compare baseline parameters. Kaplan-Meier estimates were used to compare survival. Cox multivariate regression was used to determine predictors for late survival. Survival data up to 20 years is 97% complete.
The groups were similar with respect to age, prior MI, LV function, and incidence of atrial fibrillation. Patients undergoing mitral repair had a higher incidence of congestive heart failure (CHF) (p < 0.0001). After surgery more repair patients required use of inotropes (p = 0.0005). Overall operative mortality was 7% and similar between groups. Ten year survival was 55% and 52% for groups 1 and 2 respectively (p = 0.2). Predictors of late mortality included age, CHF, LV dimensions and LV dysfunction. Neither the addition of a mitral procedure and type of ring implanted nor residual MR after surgery, emerged as predictors of survival.
In patients with moderate ischemic MR, neither operative mortality nor long term survival are affected by the performance of a restrictive annuloplasty. For patients with CHF, mitral repair may be beneficial in terms of survival.
中度缺血性二尖瓣反流(IMR)患者的最佳手术方法仍未确定。我们研究了接受冠状动脉搭桥术(CABG)的中度IMR患者的长期预后,并比较了单纯CABG患者与同期接受限制性瓣环成形术患者的预后。
1993年至2011年间,231例中度IMR患者接受了CABG:第1组(n = 186)接受单纯CABG,第2组(n = 15)接受CABG并同期进行二尖瓣瓣环成形术。采用单因素分析比较基线参数。采用Kaplan-Meier估计法比较生存率。采用Cox多因素回归分析确定晚期生存的预测因素。长达20年的生存数据完整性为97%。
两组在年龄、既往心肌梗死、左心室功能和房颤发生率方面相似。接受二尖瓣修复的患者充血性心力衰竭(CHF)发生率较高(p < 0.0001)。术后更多接受修复的患者需要使用血管活性药物(p = 0.0005)。总体手术死亡率为7%,两组相似。第1组和第2组的10年生存率分别为55%和52%(p = 0.2)。晚期死亡的预测因素包括年龄、CHF、左心室大小和左心室功能障碍。二尖瓣手术的附加操作、植入环的类型以及术后残余二尖瓣反流均未成为生存的预测因素。
在中度缺血性二尖瓣反流患者中,限制性瓣环成形术的实施既不影响手术死亡率,也不影响长期生存率。对于CHF患者,二尖瓣修复在生存方面可能有益。