Simmen Rosalia C M, Heard Melissa E, Simmen Angela M, Montales Maria Theresa M, Marji Meera, Scanlon Samantha, Pabona John Mark P
Department of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA
Department of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
J Mol Endocrinol. 2015 Apr;54(2):R89-R101. doi: 10.1530/JME-14-0310. Epub 2015 Feb 5.
Female reproductive tract pathologies arise largely from dysregulation of estrogen and progesterone receptor signaling, leading to aberrant cell proliferation, survival, and differentiation. The signaling pathways orchestrated by these nuclear receptors are complex, require the participation of many nuclear proteins serving as key binding partners or targets, and involve a range of paracrine and autocrine regulatory circuits. The members of the Krüppel-like factor (KLF) family of transcription factors are ubiquitously expressed in reproductive tissues and have been increasingly implicated as critical co-regulators and integrators of steroid hormone actions. Herein, we explore the involvement of KLF family members in uterine pathology, describe their currently known molecular mechanisms, and discuss their potential as targets for therapeutic intervention.
女性生殖道疾病很大程度上源于雌激素和孕激素受体信号失调，导致细胞异常增殖、存活和分化。由这些核受体精心编排的信号通路很复杂，需要许多作为关键结合伙伴或靶点的核蛋白参与，并且涉及一系列旁分泌和自分泌调节回路。Krüppel样因子（KLF）转录因子家族成员在生殖组织中广泛表达，并且越来越多地被认为是类固醇激素作用的关键共调节因子和整合者。在此，我们探讨KLF家族成员在子宫疾病中的作用，描述其目前已知的分子机制，并讨论它们作为治疗干预靶点的潜力。
