Schardijn G H, Kastelein J J, Statius van Eps L W
Ned Tijdschr Geneeskd. 1989 Mar 18;133(11):556-9.
Two patients admitted after ingestion of 80% acetic acid are described. Only the first patient developed haemolysis, slight intravascular coagulation and oliguric kidney insufficiency. They were treated with a nasogastric tube and total parenteral feeding. During the first week after admission urinary excretion of beta 2-microglobulin, alanine-aminopeptidase and N-acetyl-glucosaminidase was significantly increased. The patients remained haemodynamically stable and did not develop fever. The above-mentioned elevated excretions returned to normal levels. Both patients showed similar patterns of tubular proteinuria. The observations in the second patient suggest a direct toxic effect of acetic acid on the proximal tubule of the kidney.
本文描述了两名摄入80%乙酸后入院的患者。仅第一名患者出现了溶血、轻度血管内凝血和少尿性肾功能不全。他们接受了鼻胃管治疗和全胃肠外营养。入院后的第一周，β2-微球蛋白、丙氨酸氨基肽酶和N-乙酰葡糖胺酶的尿排泄量显著增加。患者血流动力学保持稳定，未出现发热。上述升高的排泄量恢复到正常水平。两名患者均表现出相似的肾小管蛋白尿模式。对第二名患者的观察结果表明，乙酸对肾近端小管有直接毒性作用。
