Goren M P, Wright R K, Horowitz M E
Cancer Chemother Pharmacol. 1986;18(1):69-73. doi: 10.1007/BF00253068.
We assessed the acute and chronic effect of multiple courses of cisplatin therapy on renal tubules by monitoring the urinary excretion of alanine aminopeptidase, N-acetyl-beta-D-glucosaminidase, and total protein. Urine specimens were obtained before and after doses of cisplatin (90 mg/m2) given to 12 patients. Each dose of cisplatin induced transient increases in enzyme excretion, followed by proteinuria 3-5 days later. Transient enzymuria after the last cisplatin dose was significantly greater than that after the first dose. Moreover, persistent increases in urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations over pretherapy levels indicated chronic renal tubular damage. Our findings disclosed striking differences between patients in susceptibility to progressive nephrotoxicity.
我们通过监测丙氨酸氨基肽酶、N-乙酰-β-D-氨基葡萄糖苷酶和总蛋白的尿排泄情况，评估了多疗程顺铂治疗对肾小管的急性和慢性影响。对12例患者给予顺铂（90mg/m²）剂量前后采集尿液标本。每次顺铂剂量均导致酶排泄短暂增加，随后在3 - 5天后出现蛋白尿。最后一剂顺铂后的短暂酶尿明显高于第一剂后的短暂酶尿。此外，尿N-乙酰-β-D-氨基葡萄糖苷酶和血清肌酐浓度持续高于治疗前水平表明存在慢性肾小管损伤。我们的研究结果揭示了患者在对进行性肾毒性易感性方面存在显著差异。
