Perez-Oso E, Colas B, Lopez-Ruiz M P, Arilla E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala de Henares, Madrid, Spain.
Neuropeptides. 1989 Apr;13(3):157-63. doi: 10.1016/0143-4179(89)90086-3.
The effects of short and long-term haloperidol treatment on somatostatin concentration and specific binding in rat cerebral cortex and hippocampus were examined using the binding ligand 125I-Tyr1-somatostatin. Haloperidol treatment did not affect the concentration of somatostatin-like immunoreactivity in the two brain areas. Nevertheless, long-term, and not short-term, haloperidol treatment decreased the number of somatostatin receptors in the cerebral cortex and hippocampus. No significant differences in the apparent binding affinity values were seen after haloperidol treatment. When added at the time of the binding assay haloperidol 34.2 microM produced a 42% and 27% decrease in cerebrocortical and hippocampal membrane somatostatin receptors respectively.
使用结合配体125I-Tyr1-生长抑素，研究了短期和长期使用氟哌啶醇治疗对大鼠大脑皮层和海马中生长抑素浓度及特异性结合的影响。氟哌啶醇治疗不影响这两个脑区中生长抑素样免疫反应性的浓度。然而，长期而非短期使用氟哌啶醇治疗会降低大脑皮层和海马中生长抑素受体的数量。氟哌啶醇治疗后，表观结合亲和力值未见显著差异。在结合试验时加入34.2微摩尔的氟哌啶醇，分别使大脑皮层和海马膜生长抑素受体减少42%和27%。
