Biesold D, Inanami O, Sato A, Sato Y
Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Neurosci Lett. 1989 Mar 13;98(1):39-44. doi: 10.1016/0304-3940(89)90370-4.
Focal electrical stimulation of the magnocellular nucleus of the basal forebrain (nucleus basalis of Meynert; NBM) or a microinjection of L-glutamate (50 nmol) into the NBM increased cerebral cortical blood flow in the parietal lobe in urethane-anesthetized rats. The vasodilative responses were elicited only ipsilateral to the site of stimulation. Most of the vasodilative responses were abolished by intravenous administrations of muscarinic and nicotinic cholinergic blocking agents (atropine 0.5 mg/kg and mecamylamine 2 mg/kg). This suggests that the cholinergic projecting system sending fibers from the NBM to the parietal lobe contributes to the vasodilation of the cortex by activating muscarinic and nicotinic cholinergic receptors.
对基底前脑大细胞核对（迈内特基底核；NBM）进行局部电刺激，或向NBM微量注射L - 谷氨酸（50纳摩尔），可增加氨基甲酸乙酯麻醉大鼠顶叶的大脑皮质血流量。血管舒张反应仅在刺激部位的同侧引发。大多数血管舒张反应可通过静脉注射毒蕈碱和烟碱胆碱能阻断剂（阿托品0.5毫克/千克和美加明2毫克/千克）而消除。这表明从NBM向顶叶发送纤维的胆碱能投射系统通过激活毒蕈碱和烟碱胆碱能受体，对皮质血管舒张起作用。
