Xia Qijun, Chen Lin
Department of General Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijin 100853, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Feb;18(2):198-200.
Perineural invasion(PNI) is one of the important routes for metastasis of gastric carcinoma and results in local recurrence and cancer pain after radical gastrectomy. The dismal prognosis of gastric cancer has been intimately associated with lymph node metastasis, hematogenous metastasis that partly caused by PNI. Nerve, vascular and lymphatic constitutes the tumor microenvironment which plays a decisive role in the development of cancer. Molecular interaction and morphological change contribute to reciprocal signaling interactions between tumor cell and nerve. However, the underlying mechanism of PNI in gastric cancer is still unclear and needs further study. Here, we present a brief review of literatures on the topic of PNI in gastric cancer.
神经周围浸润（PNI）是胃癌转移的重要途径之一，可导致根治性胃切除术后局部复发和癌痛。胃癌的不良预后与淋巴结转移、部分由PNI引起的血行转移密切相关。神经、血管和淋巴管构成肿瘤微环境，在癌症发展中起决定性作用。分子相互作用和形态变化促成肿瘤细胞与神经之间的相互信号传导。然而，胃癌中PNI的潜在机制仍不清楚，需要进一步研究。在此，我们简要综述关于胃癌中PNI这一主题的文献。
