Welk Blayne, Al-Hothi Hana'a, Winick-Ng Jennifer, Chou Queena, MacMillan Barry, Lawendy Abdel-Rahman
Department of Surgery and Epidemiology and Biostatistics, Western University, Room B4-667, St Joseph's Health Care, 268 Grosvenor Street, London, ON, N6A 4V2, Canada,
Int Urogynecol J. 2015 Jun;26(6):805-11. doi: 10.1007/s00192-014-2624-2. Epub 2015 Feb 6.
Pelvic fractures in women significantly disrupt the pelvic floor, which may cause stress urinary incontinence (SUI) or pelvic organ prolapse (POP). Our objective was to assess the incidence of operative treatment for SUI and POP after pelvic fracture.
We used administrative data from Ontario, Canada, to conduct a retrospective cohort study. Female patients who underwent operative repair of a pelvic fracture between 2002 and 2010 were identified. The primary outcomes were the subsequent surgical treatment of SUI or POP. To compare the incidence with that of the general population, patients who had operative repair of a pelvic fracture were matched (1:2) to a person in the general population (with a propensity score to account for measurable potential confounders). Our primary analysis was a Cox proportional hazards model to compare hazard ratios (HR) in subjects with a pelvic facture and those without.
We identified 390 female patients with a median age of 47 (IQR 30-67) years. Our median follow-up period was 5.9 (4.1-8.3) years. The absolute risk of SUI surgery after pelvic fracture was 3.3 % (13 out of 390) compared with 1.0 % (8 out of 769) in the matched general population sample. The HR for SUI surgery was 5.8 (95 % CI 2.2-15.1). The absolute risk of POP surgery after pelvic fracture was 1.8 % (7 out of 390) compared with 0.9 % (7 out of 769) in the matched general population. The HR for POP surgery was 2.3 (95 % CI 0.9-5.8).
Among patients who had a pelvic fracture requiring operative repair, there appears to be a significantly increased chance of surgery for SUI, but not for POP.
女性骨盆骨折会严重破坏盆底结构,这可能导致压力性尿失禁(SUI)或盆腔器官脱垂(POP)。我们的目的是评估骨盆骨折后SUI和POP手术治疗的发生率。
我们使用来自加拿大安大略省的行政数据进行回顾性队列研究。确定了2002年至2010年间接受骨盆骨折手术修复的女性患者。主要结局是SUI或POP的后续手术治疗。为了将发生率与普通人群进行比较,对接受骨盆骨折手术修复的患者与普通人群中的个体进行匹配(1:2)(使用倾向评分来考虑可测量的潜在混杂因素)。我们的主要分析是Cox比例风险模型,以比较骨盆骨折患者和无骨盆骨折患者的风险比(HR)。
我们确定了390名女性患者,中位年龄为47岁(四分位间距30 - 67岁)。我们的中位随访期为5.9年(4.1 - 8.3年)。骨盆骨折后SUI手术的绝对风险为3.3%(390例中有13例),而匹配的普通人群样本中为1.0%(769例中有8例)。SUI手术的HR为5.8(95%可信区间2.2 - 15.1)。骨盆骨折后POP手术的绝对风险为1.8%(390例中有7例),而匹配的普通人群中为0.9%(769例中有7例)。POP手术的HR为2.3(95%可信区间0.9 - 5.8)。
在需要手术修复骨盆骨折的患者中,SUI手术的可能性似乎显著增加,但POP手术并非如此。