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阴道分娩或剖宫产与压力性尿失禁或盆腔器官脱垂的后续发展之间的关联:一项基于人群的回顾性队列研究。

Association between vaginal or cesarean delivery and later development of stress urinary incontinence or pelvic organ prolapse: A retrospective population-based cohort study.

机构信息

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, 970, Taiwan.

Tzu Chi University Research Center for Big Data Teaching, Research and Statistic Consultation, Tzu Chi University, Hualien, 970, Taiwan.

出版信息

Int Urogynecol J. 2023 Sep;34(9):2041-2047. doi: 10.1007/s00192-023-05504-6. Epub 2023 Mar 14.

Abstract

INTRODUCTION AND HYPOTHESIS

Child delivery mode may be associated with pelvic floor disorders. We explored the association between different delivery modes and later development of stress urinary incontinence (SUI) and pelvic organ prolapse (POP) in Taiwanese women.

METHODS

This was a retrospective population-based cohort study. Women who delivered babies between January 1, 2000, and December 31, 2018, were selected for this study. The study used Taiwan's National Health Insurance (NHI) Research Database. After propensity score matching, 51,587 women who underwent cesarean section (C/S) and 51,587 women who underwent vaginal delivery (VD) were recruited. Primary outcomes were the presence of SUI and POP after delivery.

RESULTS

The incidence of SUI (1.6/1000 person-years) and POP (1.5/1000 person-years) was higher in the VD group than in the C/S group (0.8 and 0.6 in 1000 person-years). VD was associated with an increased risk of SUI [hazard ratio (HR): 2.79, 95% confidence interval (CI): 2.45-3.17] and POP (HR: 1.96, 95% CI: 1.75-2.19) compared to C/S. We also found that age (HR: 1.06, 95% CI: 1.05-1.08 in SUI, HR: 1.08, 95% CI: 1.07-1.09 in POP) and Charlson Comorbidity Index (CCI) (HR: 1.28, 95% CI: 1.12-1.46 in SUI, HR: 1.27, 95% CI: 1.13-1.43 in POP) were associated with an increased risk of SUI and POP. The cumulative incidence of SUI and POP was higher in the VD group than in the C/S group (log-rank test, P < 0.05).

CONCLUSIONS

The current study was the largest retrospective cohort study regarding the influence of delivery mode on SUI and POP so far. VD was found to be associated with an increased risk of SUI and POP compared with C/S. Postpartum care for pelvic physical therapy should be provided particularly to women undergoing VD.

摘要

引言与假设

分娩方式可能与盆底功能障碍有关。本研究旨在探讨台湾女性不同分娩方式与产后压力性尿失禁(SUI)和盆腔器官脱垂(POP)的关系。

方法

这是一项回顾性基于人群的队列研究。选择 2000 年 1 月 1 日至 2018 年 12 月 31 日期间分娩的女性进行本研究。本研究使用了台湾全民健康保险研究数据库。通过倾向评分匹配后,纳入了 51587 名剖宫产(CS)和 51587 名阴道分娩(VD)的女性。主要结局是产后 SUI 和 POP 的发生情况。

结果

VD 组的 SUI(1.6/1000 人年)和 POP(1.5/1000 人年)发生率高于 CS 组(0.8 和 0.6/1000 人年)。与 CS 相比,VD 与 SUI(风险比[HR]:2.79,95%置信区间[CI]:2.45-3.17)和 POP(HR:1.96,95% CI:1.75-2.19)的风险增加相关。我们还发现,年龄(SUI:HR:1.06,95% CI:1.05-1.08;POP:HR:1.08,95% CI:1.07-1.09)和 Charlson 合并症指数(CCI)(SUI:HR:1.28,95% CI:1.12-1.46;POP:HR:1.27,95% CI:1.13-1.43)与 SUI 和 POP 的风险增加相关。与 CS 组相比,VD 组的 SUI 和 POP 累积发生率更高(对数秩检验,P<0.05)。

结论

本研究是迄今为止关于分娩方式对 SUI 和 POP 影响的最大回顾性队列研究。与 CS 相比,VD 与 SUI 和 POP 的风险增加相关。对于行 VD 的女性,产后应特别提供盆底物理治疗的产后护理。

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