Girchev R, Toneva Z, Natcheff N
Department of Physiology, Medical Academy Sofia, Bulgaria.
Acta Physiol Hung. 1989;73(1):53-60.
The experiments were carried out on female dogs with exteriorized ureters prior to and following surgical denervation of the left kidney. Propranolol 1.0 mg/kg b.w. was administered intravenously. Sodium, potassium, chloride, calcium, magnesium, zinc, copper, creatinine and urea concentrations in the urine from the denervated and intact kidneys as well as in blood drawn were determined. After renal denervation PAH clearance was determined. As a result of denervation diuresis and calcium and copper excretion were increased while urine osmolality was diminished. No change occurred in kidney blood flow and GFR. After propranolol administration diuresis, calcium and copper excretion in the intact kidney significantly increased. Changes in the excretory function of the left kidney following its denervation were not a result of alterations in renal haemodynamics. Results obtained indicative of that beta-adrenergic receptors contribute to the excretion of calcium and copper ions.
实验在左肾手术去神经前后的输尿管外置的雌性犬身上进行。静脉注射1.0毫克/千克体重的普萘洛尔。测定去神经和完整肾脏尿液以及所抽取血液中的钠、钾、氯、钙、镁、锌、铜、肌酐和尿素浓度。肾去神经后测定对氨基马尿酸清除率。去神经导致利尿以及钙和铜排泄增加，而尿渗透压降低。肾血流量和肾小球滤过率无变化。给予普萘洛尔后，完整肾脏的利尿、钙和铜排泄显著增加。左肾去神经后其排泄功能的变化并非肾血流动力学改变的结果。所得结果表明β-肾上腺素能受体有助于钙和铜离子的排泄。
