Tost H, Herceg R, Kövér G
Acta Physiol Acad Sci Hung. 1982;59(1):1-13.
The effect of renal function of an augmentation of the excretory renal mass was investigated in 10 dogs without drug treatment and in 10 animals with alpha-receptor blockade. In the untreated group, augmentation of excretory renal mass by transplantation into the neck of one pair of kidneys isolated from another animal caused the following changes in the kidneys in situ: marked elevation in CPAH, slight decrease in Cinulin, slight diminution of urine excretion and a pronounced fall in sodium excretion. The amount of urine and sodium excreted by the four kidneys was identical with that previously excreted by the two kidneys in situ. In animals with alpha-receptor blockade, augmentation of the excretory renal mass had the following consequences in the in situ kidneys, CPAH, and Cinulin remained unchanged while urine and sodium excretion decreased to the same extent as in the untreated control group. The amount of urine and of sodium excreted by the four kidneys was the same as that excreted by the kidneys in situ, prior to transplantation of isolated kidneys, i.e. before the augmentation of excretory renal mass. It seems that the decrease in sodium excretion of the kidneys in situ was not due to the haemodynamic changes evoked by the load on the circulation; it was rather consequence of some quick, presumably humoral, regulation. The diminution of sodium excretion in the kidneys in situ after augmentation of the excretory renal mass has been ascribed to an increased utilization by the four kidneys of the natriuretic factor(s), i.e. to a diminution in the plasma level of the natriuretic hormone.
在10只未接受药物治疗的狗和10只接受α受体阻断的动物中，研究了增加肾脏排泄质量对肾功能的影响。在未治疗组中，将从另一只动物分离的一对肾脏移植到颈部以增加排泄性肾脏质量，导致原位肾脏出现以下变化：对氨基马尿酸清除率（CPAH）显著升高，菊粉清除率（Cinulin）略有下降，尿量略有减少，钠排泄量显著下降。四个肾脏排出的尿液和钠的量与之前两个原位肾脏排出的量相同。在接受α受体阻断的动物中，增加排泄性肾脏质量对原位肾脏产生了以下影响，CPAH和Cinulin保持不变，而尿量和钠排泄量下降的程度与未治疗的对照组相同。四个肾脏排出的尿液和钠的量与移植孤立肾脏之前原位肾脏排出的量相同，即在增加排泄性肾脏质量之前。似乎原位肾脏钠排泄的减少不是由于循环负荷引起的血流动力学变化；这更可能是某种快速的、大概是体液调节的结果。排泄性肾脏质量增加后原位肾脏钠排泄的减少归因于四个肾脏对利钠因子的利用率增加，即利钠激素血浆水平的降低。
