Ivry Elisa, Ben-Asuly Amos, Goldberg Israel, Lemcoff N Gabriel
Chemistry Department, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Chem Commun (Camb). 2015 Mar 4;51(18):3870-3. doi: 10.1039/c5cc00052a.
Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.
通过简便的阴离子配体交换，将几种氨基酸配体引入到第二代霍维达-格鲁布斯络合物中。所得到的手性预催化剂在不对称闭环和开环交叉复分解反应中表现出对映选择性。发现降低羧酸盐配体的不稳定性对于提高所观察到的对映体产物富集至关重要。
