Oh Yoon-Sang, Kim Joong-Seok, Park In-Seok, Shim Yong-Soo, Song In-Uk, Park Jeong-Wook, Lee Phil-Hyu, Lyoo Chul-Hyung, Ahn Tae-Beom, Ma Hyo-Il, Kim Yong-Duk, Koh Seong-Beom, Lee Seung-Jae, Lee Kwang-Soo
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Geriatr Gerontol Int. 2016 Feb;16(2):230-6. doi: 10.1111/ggi.12457. Epub 2015 Feb 5.
The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD).
A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed.
Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used.
The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.
本研究旨在调查帕金森病（PD）患者中痴呆和轻度认知障碍（MCI）的时点患病率。
本研究纳入了来自12家医院的1200例PD患者。所有患者被分为认知正常、MCI和痴呆亚组。采用韩国版简易精神状态检查表、临床痴呆评定量表和总体衰退量表评估总体认知状态和痴呆严重程度，采用Hoehn和Yahr分期评分评估帕金森运动状态。检查相关睡眠行为和其他医疗状况。分析抗痴呆药物的处方模式。
PD患者中认知障碍很常见；38.9%的患者存在MCI，而38.3%的患者存在痴呆。认知障碍的患病率随年龄增长和病程延长而增加，姿势不稳症状和类似快速眼动睡眠行为障碍的症状与认知障碍相关。许多痴呆患者（95.2%）和23.6%的MCI患者接受了抗痴呆药物治疗，其中卡巴拉汀使用最为频繁。
PD患者中认知障碍的时点患病率为77.2%。认知障碍与年龄、病程以及特定的帕金森运动/非运动症状相关。超过90%的痴呆患者接受了抗痴呆药物治疗，卡巴拉汀是治疗痴呆最常用的药物。
