结直肠癌中的转移前 NOTCH 信号传导。
Prometastatic NOTCH Signaling in Colon Cancer.
机构信息
University Medical Center Utrecht, Utrecht, the Netherlands.
出版信息
Cancer Discov. 2015 Feb;5(2):115-7. doi: 10.1158/2159-8290.CD-14-1456.
PMID:25656897
Abstract
Dysregulation of NOTCH signaling contributes to the development of colorectal cancer, but how this pathway regulates metastasis has so far remained unclear. Sonoshita and colleagues identified a novel NOTCH-driven metastasis pathway that is amenable to therapeutic intervention and generated a companion diagnostic tool that allows analysis of pathway activity in human tumor tissue sections.
摘要
NOTCH 信号通路的失调导致了结直肠癌的发生，但该通路如何调节转移至今仍不清楚。Sonoshita 及其同事发现了一种新的 NOTCH 驱动的转移途径，该途径可进行治疗干预，并生成了一种伴随诊断工具，可用于分析人类肿瘤组织切片中的途径活性。
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