Vinson Kaitlyn E, George Dennis C, Fender Alexander W, Bertrand Fred E, Sigounas George
Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC.
Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL.
Int J Cancer. 2016 Apr 15;138(8):1835-42. doi: 10.1002/ijc.29800. Epub 2015 Aug 27.
Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. It is also the third most common cancer diagnosis among men, and the second most common cancer diagnosis among women. Globally, CRC can account for nearly 694,000 annual deaths. It is widely appreciated that CRC is the result of dysregulated cellular pathways that promote an inappropriate stem-cell-like phenotype, apoptotic resistance, unchecked proliferation and metastatic spread. While no single pathway is responsible for all of these attributes, an array of recent studies suggests a pivotal role for abnormal Notch-1 signaling in CRC, in part due to interconnectivity of Notch with other pathways. This review will summarize recent evidence for a role of Notch signaling in CRC, will consider interconnectivity between Notch and other pathways involved in CRC and will discuss the possible utility of targeting Notch as a CRC therapeutic.
结直肠癌（CRC）是全球癌症死亡的第三大主要原因。它也是男性中第三常见的癌症诊断类型，女性中第二常见的癌症诊断类型。在全球范围内，CRC每年可导致近69.4万人死亡。人们普遍认识到，CRC是细胞通路失调的结果，这些通路促进了不适当的干细胞样表型、凋亡抗性、不受控制的增殖和转移扩散。虽然没有单一的通路对所有这些特征负责，但一系列近期研究表明，异常的Notch-1信号在CRC中起关键作用，部分原因是Notch与其他通路的相互连接。本综述将总结Notch信号在CRC中作用的最新证据，考虑Notch与CRC中其他相关通路之间的相互连接，并讨论将Notch作为CRC治疗靶点的潜在效用。
