Wang Chung-Chieh, De Marzo Angelo M, Lotan Tamara L, Epstein Jonathan I
Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan 100.
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231.
Hum Pathol. 2015 Apr;46(4):554-7. doi: 10.1016/j.humpath.2014.12.007. Epub 2014 Dec 31.
Small cell carcinoma (SmCC) of the prostate is a rare and aggressive histologic subtype of the prostate cancer. It can sometimes mimic acinar adenocarcinoma with a high Gleason score (GS). A previous study showed that immunohistochemical staining for CD44 could help in the differential diagnosis of these 2 entities. In this study, we used 2 tissue microarrays including 63 cases of prostate cancer (18 pure SmCC, 37 pure acinar adenocarcinoma, and 8 mixed acinar adenocarcinoma and SmCC) to validate the value of CD44. When analyzed as a continuous variable, CD44 positivity was significantly higher in acinar adenocarcinoma with GS 8 than GS 9 to 10 (P = .027). However, the difference of CD44 expression between SmCC and acinar adenocarcinoma was insignificant. The current study fails to confirm the value of CD44 in differential diagnosis between prostatic SmCC and acinar adenocarcinoma.
前列腺小细胞癌（SmCC）是前列腺癌中一种罕见且侵袭性强的组织学亚型。它有时可模拟高Gleason评分（GS）的腺泡腺癌。先前的一项研究表明，CD44免疫组化染色有助于这两种实体的鉴别诊断。在本研究中，我们使用了2个组织芯片，包括63例前列腺癌病例（18例纯SmCC、37例纯腺泡腺癌以及8例腺泡腺癌与SmCC混合病例）来验证CD44的价值。当将CD44作为连续变量分析时，GS为8的腺泡腺癌中CD44阳性率显著高于GS为9至10的腺泡腺癌（P = 0.027）。然而，SmCC与腺泡腺癌之间CD44表达的差异无统计学意义。本研究未能证实CD44在前列腺SmCC与腺泡腺癌鉴别诊断中的价值。
