Takaue Y, Watanabe T, Kawano Y, Abe T, Suzue T, Satoh J, Kamata K, Huq M A, Ninomiya T, Kuroda Y
Dept. of Pediatrics, University of Tokushima.
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 1):781-6.
Hematopoietic recovery kinetics was evaluated in five children with therapy-refractory cancers who received peripheral blood stem cell autotransplantation (PBSCT) following marrow-ablative chemotherapy. Four children received graft containing more than 1.5 X 10(4) CFU-GM/kg and days required to achieve granulocyte counts of greater than 0.5 X 10(9)/l were 6, 10, 13, and 18, respectively. One patient received 0.9 X 10(4) CFU-GM/kg, but, recovery of granulopoiesis was retarded (greater than 30 days). The days required to achieve platelet count of greater than 50 X 10(9)/l were 12, 15, 16, 195, and greater than 240, respectively. Transient decrease of blood cell counts developed 3 to 5 weeks after transplantation and thereafter, the recovery of hematopoiesis became stable. With the use of a large number of progenitors, PBSCT seems to be safe and effective new type of stem cell rescue operation as an alternative to bone marrow transplantation.
对五名患有难治性癌症的儿童进行了造血恢复动力学评估，这些儿童在进行清髓性化疗后接受了外周血干细胞自体移植（PBSCT）。四名儿童接受了含有超过1.5×10⁴CFU-GM/kg的移植物，达到粒细胞计数大于0.5×10⁹/L所需的天数分别为6天、10天、13天和18天。一名患者接受了0.9×10⁴CFU-GM/kg，但粒细胞生成恢复延迟（大于30天）。达到血小板计数大于50×10⁹/L所需的天数分别为12天、15天、16天、195天和大于240天。移植后3至5周出现血细胞计数短暂下降，此后，造血恢复变得稳定。使用大量祖细胞后，PBSCT作为骨髓移植的替代方法，似乎是一种安全有效的新型干细胞救援手术。
