Taylor Nordgård Catherine, Draget Kurt I
Department of Biotechnology, Norwegian University of Science and Technology (NTNU), Norway.
Department of Biotechnology, Norwegian University of Science and Technology (NTNU), Norway.
Eur J Pharm Biopharm. 2015 Sep;95(Pt A):144-50. doi: 10.1016/j.ejpb.2015.01.024. Epub 2015 Feb 2.
Mucus in the small intestine acts as both a lubricant and a barrier to reduce mucosal exposure to damaging agents, and must perform these functions in a highly mechanically dynamic environment, both in terms of luminal shear and gut wall contractility. Here we investigate the dynamic responses of ex vivo pig small intestinal mucus to applied shear of different magnitudes over different timescales. At low levels of applied stress of 1Pa, which is of the order of magnitude of that induced by gut wall contractility, the mucus demonstrates stress hardening responses to the applied deformation. This hardening behavior is lost at higher levels of applied stress. Such hardening behavior is likely to contribute to the ability of small intestinal mucus to maintain a barrier at the mucosal surface in the mechanically dynamic gut environment.
小肠中的黏液既充当润滑剂，又作为一种屏障，以减少黏膜与损伤因子的接触，并且必须在高度机械动态的环境中履行这些功能，无论是在管腔剪切力还是肠壁收缩性方面。在此，我们研究了离体猪小肠黏液在不同时间尺度上对不同大小的外加剪切力的动态响应。在1Pa的低外加应力水平下（这与肠壁收缩性所诱导的应力大小相当），黏液对外加变形表现出应力硬化响应。在较高的外加应力水平下，这种硬化行为消失。这种硬化行为可能有助于小肠黏液在机械动态的肠道环境中在黏膜表面维持屏障功能。
